UniProt Accession

 CAPZB_HUMAN; P47756; Q32Q68; Q5U0L4; Q8TB49; Q9NUC4 

Genbank Protein ID

 U03271; BT019470; BT019471; AL035413; AL359199; AL445163; AL359199; AL035413; AL445163; AL445163; AL035413; AL359199; CH471134; BC024601; BC107752; BC109241; BC109242 

Genbank Nucleotide ID

 AAA87395.1; AAV38277.1; AAV38278.1; CAI22231.1; CAI22231.1; CAI22231.1; CAH72124.1; CAH72124.1; CAH72124.1; CAH71392.1; CAH71392.1; CAH71392.1; EAW94890.1; AAH24601.1; AAI07753.1; AAI09242.1; AAI09243.1 

Protein Name

 F-actin-capping protein subunit beta 

Protein Synonyms/Alias

 CapZ beta 

Gene Name

 CAPZB 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
78	YRSPWSNKYDPPLED	ubiquitination	[1]
235	LNEIYFGKTKDIVNG	ubiquitination	[1]
267	NDLVEALKRKQQC**	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization. 

Sequence Annotation

 MOD_RES 2 2 N-acetylserine.
 MOD_RES 182 182 Phosphoserine (By similarity).
 MOD_RES 235 235 N6-acetyllysine.  

Keyword

 Acetylation; Actin capping; Actin-binding; Alternative splicing; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 277 AA 

Protein Sequence

Gene Ontology

 GO:0030863; C:cortical cytoskeleton; IEA:Compara.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0008290; C:F-actin capping protein complex; TAS:ProtInc.
 GO:0030027; C:lamellipodium; IEA:Compara.
 GO:0016020; C:membrane; IEA:Compara.
 GO:0030017; C:sarcomere; IEA:UniProtKB-SubCell.
 GO:0071203; C:WASH complex; IDA:UniProtKB.
 GO:0003779; F:actin binding; TAS:ProtInc.
 GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
 GO:0051693; P:actin filament capping; IEA:UniProtKB-KW.
 GO:0007596; P:blood coagulation; TAS:Reactome.
 GO:0006928; P:cellular component movement; TAS:UniProtKB.
 GO:0007010; P:cytoskeleton organization; IMP:UniProtKB.
 GO:0030032; P:lamellipodium assembly; IEA:Compara.
 GO:0022604; P:regulation of cell morphogenesis; IMP:UniProtKB. 

Interpro

 IPR019771; F-actin_capping_bsu_CS.
 IPR001698; WASH_F-actin_cap_beta. 

Pfam

 PF01115; F_actin_cap_B 

SMART

  

PROSITE

 PS00231; F_ACTIN_CAPPING_BETA 

PRINTS

 PR00192; FACTINCAPB.