UniProt Accession

 WBS22_HUMAN; O43709; A8K501; Q96P12; Q9BQ58; Q9HBP9 

Genbank Protein ID

 AF420248; AJ224442; AF412034; AK291116; AK315032; AF218007; AC073846; CH471200; BC000169; BC001780; BC011696 

Genbank Nucleotide ID

 AAL16066.1; CAA11944.1; AAM62316.1; BAF83805.1; BAG37517.1; AAG17249.1; AAS07473.1; EAW69657.1; AAH00169.2; AAH01780.2; AAH11696.2 

Protein Name

 Uncharacterized methyltransferase WBSCR22 

Protein Synonyms/Alias

 Williams-Beuren syndrome chromosomal region 22 protein 

Gene Name

 WBSCR22 

Gene Synonyms/Alias

 HUSSY-03; PP3381 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
180	LITTQATKAGFSGGM	ubiquitination	[1]
196	VDYPNSAKAKKFYLC	ubiquitination	[1, 2]
255	SRAWVLEKKERHRRQ	ubiquitination	[2, 3, 4]
256	RAWVLEKKERHRRQG	ubiquitination	[3]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.
 Danielsen JM, Sylvestersen KB, Bekker-Jensen S, Szklarczyk D, Poulsen JW, Horn H, Jensen LJ, Mailand N, Nielsen ML.
 Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. [PMID: 21139048]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

 Methyltransferase that may act on DNA. 

Sequence Annotation

  

Keyword

 Alternative splicing; Complete proteome; Methyltransferase; Nucleus; Reference proteome; Transferase; Williams-Beuren syndrome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 281 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0008168; F:methyltransferase activity; NAS:UniProtKB. 

Interpro

 IPR013216; Methyltransf_11.
 IPR022238; Unchr_MeTrfase_Williams-Beuren. 

Pfam

 PF08241; Methyltransf_11
 PF12589; WBS_methylT 

SMART

  

PROSITE

  

PRINTS