CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018108
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sodium- and chloride-dependent creatine transporter 1 
Protein Synonyms/Alias
 CT1; Creatine transporter 1; Solute carrier family 6 member 8 
Gene Name
 Slc6a8 
Gene Synonyms/Alias
 Crt 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
18YSVSGDEKKGPLIVSubiquitination[1]
33GPDGAPAKGDGPAGLubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Required for the uptake of creatine. Plays an important role in supplying creatine to the brain via the blood-brain barrier. 
Sequence Annotation
 CARBOHYD 192 192 N-linked (GlcNAc...) (Potential).
 CARBOHYD 197 197 N-linked (GlcNAc...) (Potential).
 CARBOHYD 553 553 N-linked (GlcNAc...) (Potential).  
Keyword
 Alternative splicing; Complete proteome; Glycoprotein; Ion transport; Membrane; Reference proteome; Sodium; Sodium transport; Symport; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 640 AA 
Protein Sequence
MAKKSAENGI YSVSGDEKKG PLIVSGPDGA PAKGDGPAGL GAPGGRLAVP PRETWTRQMD 60
FIMSCVGFAV GLGNVWRFPY LCYKNGGGVF LIPYVLIALV GGIPIFFLEI SLGQFMKAGS 120
INVWNICPLF KGLGYASMVI VFYCNTYYIM VLAWGFYYLV KSFTTTLPWA TCGHTWNTPD 180
CVEIFRHEDC ANASLANLTC DQLADRRSPV IEFWENKVLR LSTGLEVPGA LNWEVTLCLL 240
ACWVLVYFCV WKGVKSTGKI VYFTATFPYV VLVVLLVRGV LLPGALDGII YYLKPDWSKL 300
GSPQVWIDAG TQIFFSYAIG LGALTALGSY NRFNNNCYKD AIILALINSG TSFFAGFVVF 360
SILGFMATEQ GVHISKVAES GPGLAFIAYP RAVTLMPVAP LWAALFFFML LLLGLDSQFV 420
GVEGFITGLL DLLPASYYFR FQREISVALC CALCFVIDLS MVTDVSGGKG GMYVFQLFDY 480
YSASGTTLLW QAFWECVVVA WVYGADRFMD DIACMIGYRP CPWMKWCWSF FTPLVCMGIF 540
IFNIVYYEPL VYNNTYVYPW WGEAMGWAFA LSSMLCVPLH LLGCLLRAKG TMAERWQHLT 600
QPIWGLHHLE YRAQDADVRG LTTLTPVSES SKVVVVESVM 640 
Gene Ontology
 GO:0005887; C:integral to plasma membrane; IEA:InterPro.
 GO:0015220; F:choline transmembrane transporter activity; IEA:Compara.
 GO:0005309; F:creatine:sodium symporter activity; IEA:InterPro.
 GO:0005328; F:neurotransmitter:sodium symporter activity; IEA:InterPro. 
Interpro
 IPR000175; Na/ntran_symport.
 IPR002984; Na/ntran_symport_creatine. 
Pfam
 PF00209; SNF 
SMART
  
PROSITE
 PS00610; NA_NEUROTRAN_SYMP_1
 PS00754; NA_NEUROTRAN_SYMP_2
 PS50267; NA_NEUROTRAN_SYMP_3 
PRINTS
 PR01199; CRTTRANSPORT.
 PR00176; NANEUSMPORT.