CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021940
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ras-related protein Rab-18 
Protein Synonyms/Alias
  
Gene Name
 RAB18 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
21IGESGVGKSSLLLRFubiquitination[1]
152VNMLVGNKIDKENREubiquitination[1]
167VDRNEGLKFARKHSMubiquitination[1]
212WESENQNKGVKLSHRubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
 Plays a role in apical endocytosis/recycling. May be implicated in transport between the plasma membrane and early endosomes. Plays a key role in eye and brain development and neurodegeneration. 
Sequence Annotation
 NP_BIND 15 23 GTP.
 NP_BIND 63 67 GTP.
 NP_BIND 122 125 GTP.
 NP_BIND 151 153 GTP.
 MOTIF 37 45 Effector region (By similarity).
 MOD_RES 1 1 N-acetylmethionine.
 MOD_RES 203 203 Cysteine methyl ester (Potential).
 LIPID 199 199 S-palmitoyl cysteine (Potential).
 LIPID 203 203 S-geranylgeranyl cysteine (By  
Keyword
 3D-structure; Acetylation; Alternative splicing; Cell membrane; Complete proteome; Developmental protein; Direct protein sequencing; GTP-binding; Lipoprotein; Membrane; Methylation; Nucleotide-binding; Palmitate; Polymorphism; Prenylation; Protein transport; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 206 AA 
Protein Sequence
MDEDVLTTLK ILIIGESGVG KSSLLLRFTD DTFDPELAAT IGVDFKVKTI SVDGNKAKLA 60
IWVTLHQQTA NFFLKSQIGN SPILKWAMWQ YDTAGQERFR TLTPSYYRGA QGVILVYDVT 120
RRDTFVKLDN WLNELETYCT RNDIVNMLVG NKIDKENREV DRNEGLKFAR KHSMLFIEAS 180
AKTCDGVQCA FEELVEKIIQ TPGLWESENQ NKGVKLSHRE EGQGGGACGG YCSVL 235 
Gene Ontology
 GO:0005622; C:intracellular; IDA:LIFEdb.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0019003; F:GDP binding; IDA:UniProtKB.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; NAS:UniProtKB.
 GO:0007420; P:brain development; ISS:UniProtKB.
 GO:0006897; P:endocytosis; NAS:UniProtKB.
 GO:0001654; P:eye development; ISS:UniProtKB.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0007264; P:small GTPase mediated signal transduction; NAS:UniProtKB. 
Interpro
 IPR027417; P-loop_NTPase.
 IPR025662; Sigma_54_int_dom_ATP-bd_1.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR003579; Small_GTPase_Rab_type. 
Pfam
 PF00071; Ras 
SMART
 SM00175; RAB 
PROSITE
 PS51419; RAB 
PRINTS
 PR00449; RASTRNSFRMNG.