UniProt Accession

 METJ_ECOLI; P0A8U6; P08338; Q2M8N4 

Genbank Protein ID

 M12869; L19201; U00096; AP009048; M38202 

Genbank Nucleotide ID

 AAA24163.1; AAB03070.1; AAC76920.1; BAE77372.1; AAA24162.1 

Protein Name

 Met repressor 

Protein Synonyms/Alias

 Met regulon regulatory protein MetJ 

Gene Name

 metJ 

Gene Synonyms/Alias

 b3938; JW3909 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
17	SPYAEHGKKSEQVKK	acetylation	[1]
18	PYAEHGKKSEQVKKI	acetylation	[1]
32	ITVSIPLKVLKILTD	acetylation	[1]
35	SIPLKVLKILTDERT	acetylation	[1]
79	PDDADLRKERSDEIP	acetylation	[1]
90	DEIPEAAKEIMREMG	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis. It is also autoregulated. 

Sequence Annotation

  

Keyword

 3D-structure; Amino-acid biosynthesis; Complete proteome; Cytoplasm; Direct protein sequencing; DNA-binding; Methionine biosynthesis; Reference proteome; Repressor; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 105 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0009086; P:methionine biosynthetic process; IEA:HAMAP.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IEA:HAMAP.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR002084; Met_repressor_MetJ.
 IPR023453; Met_repressor_MetJ_dom.
 IPR010985; Ribbon_hlx_hlx. 

Pfam

 PF01340; MetJ 

SMART

  

PROSITE

  

PRINTS