CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005895
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Aryl hydrocarbon receptor 
Protein Synonyms/Alias
 Ah receptor; AhR 
Gene Name
 Ahr 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
23KPVQKTVKPIPAEGIacetylation[1]
62FPQDVINKLDKLSVLubiquitination[2]
87SFFDVALKSTPADRNubiquitination[2]
432TKSNTSRKDWAPQSTubiquitination[2]
Reference
 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. 
Sequence Annotation
 DOMAIN 26 79 bHLH.
 DOMAIN 116 179 PAS 1.
 DOMAIN 269 336 PAS 2.
 DOMAIN 342 380 PAC.  
Keyword
 Activator; Cell cycle; Complete proteome; Cytoplasm; Direct protein sequencing; DNA-binding; Nucleus; Polymorphism; Receptor; Reference proteome; Repeat; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 848 AA 
Protein Sequence
MSSGANITYA SRKRRKPVQK TVKPIPAEGI KSNPSKRHRD RLNTELDRLA SLLPFPQDVI 60
NKLDKLSVLR LSVSYLRAKS FFDVALKSTP ADRNGGQDQC RAQIRDWQDL QEGEFLLQAL 120
NGFVLVVTAD ALVFYASSTI QDYLGFQQSD VIHQSVYELI HTEDRAEFQR QLHWALNPDS 180
AQGVDEAHGP PQAAVYYTPD QLPPENASFM ERCFRCRLRC LLDNSSGFLA MNFQGRLKYL 240
HGQNKKGKDG ALLPPQLALF AIATPLQPPS ILEIRTKNFI FRTKHKLDFT PIGCDAKGQL 300
ILGYTEVELC TRGSGYQFIH AADMLHCAES HIRMIKTGES GMTVFRLFAK HSRWRWVQSN 360
ARLIYRNGRP DYIIATQRPL TDEEGREHLQ KRSTSLPFMF ATGEAVLYEI SSPFSPIMDP 420
LPIRTKSNTS RKDWAPQSTP SKDSFHPSSL MSALIQQDES IYLCPPSSPA PLDSHFLMGS 480
VSKCGSWQDS FAAAGSEAAL KHEQIGHAQD VNLALSGGPS ELFPDNKNND LYNIMRNLGI 540
DFEDIRSMQN EEFFRTDSTA AGEVDFKDID ITDEILTYVQ DSLNNSTLMN SACQQQPVTQ 600
HLSCMLQERL QLEQQQQLQQ PPPQALEPQQ QLCQMVCPQQ DLGPKHTQIN GTFASWNPTP 660
PVSFNCPQQE LKHYQLFSSL QGTAQEFPYK PEVDSVPYTQ NFAPCNQPLL PEHSKSVQLD 720
FPGRDFEPSL HPTTSNLDFV SCLQVPENQS HGINSQSTMV SPQAYYAGAM SMYQCQPGPQ 780
RTPVDQTQYS SEIPGSQAFL SKVQSRGIFN ETYSSDLSSI GHAAQTTGHL HHLAEARPLP 840
DITPGGFL 848 
Gene Ontology
 GO:0034752; C:cytosolic aryl hydrocarbon receptor complex; TAS:DFLAT.
 GO:0034753; C:nuclear aryl hydrocarbon receptor complex; TAS:DFLAT.
 GO:0005667; C:transcription factor complex; TAS:MGI.
 GO:0051879; F:Hsp90 protein binding; TAS:DFLAT.
 GO:0004879; F:ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; IDA:UniProtKB.
 GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; IDA:MGI.
 GO:0043565; F:sequence-specific DNA binding; IDA:MGI.
 GO:0006915; P:apoptotic process; IDA:UniProtKB.
 GO:0030183; P:B cell differentiation; TAS:DFLAT.
 GO:0001922; P:B-1 B cell homeostasis; TAS:DFLAT.
 GO:0001974; P:blood vessel remodeling; IMP:DFLAT.
 GO:0043010; P:camera-type eye development; IMP:DFLAT.
 GO:0007049; P:cell cycle; IDA:UniProtKB.
 GO:0000902; P:cell morphogenesis; IMP:DFLAT.
 GO:0071320; P:cellular response to cAMP; IDA:UniProtKB.
 GO:0003243; P:circumferential growth involved in left ventricle morphogenesis; IMP:DFLAT.
 GO:0061009; P:common bile duct development; IMP:DFLAT.
 GO:0035162; P:embryonic hemopoiesis; IMP:DFLAT.
 GO:0072102; P:glomerulus morphogenesis; IMP:DFLAT.
 GO:0060993; P:kidney morphogenesis; IMP:DFLAT.
 GO:0001889; P:liver development; IMP:DFLAT.
 GO:0060547; P:negative regulation of necrotic cell death; IMP:DFLAT.
 GO:0003085; P:negative regulation of systemic arterial blood pressure; IMP:DFLAT.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:MGI.
 GO:0045906; P:negative regulation of vasoconstriction; IMP:DFLAT.
 GO:0001569; P:patterning of blood vessels; IMP:DFLAT.
 GO:0045793; P:positive regulation of cell size; IMP:DFLAT.
 GO:0040010; P:positive regulation of growth rate; IMP:DFLAT.
 GO:0045899; P:positive regulation of RNA polymerase II transcriptional preinitiation complex assembly; IDA:MGI.
 GO:0035166; P:post-embryonic hemopoiesis; IMP:DFLAT.
 GO:0030850; P:prostate gland development; IMP:MGI.
 GO:0050880; P:regulation of blood vessel size; IMP:DFLAT.
 GO:0060420; P:regulation of heart growth; TAS:DFLAT.
 GO:0006950; P:response to stress; IDA:UniProtKB.
 GO:0009636; P:response to toxic substance; IDA:UniProtKB.
 GO:0048745; P:smooth muscle tissue development; IMP:DFLAT.
 GO:0048536; P:spleen development; IMP:DFLAT.
 GO:0043029; P:T cell homeostasis; IMP:DFLAT.
 GO:0060841; P:venous blood vessel development; IMP:DFLAT.
 GO:0006805; P:xenobiotic metabolic process; TAS:MGI. 
Interpro
 IPR011598; bHLH_dom.
 IPR001610; PAC.
 IPR000014; PAS.
 IPR013767; PAS_fold.
 IPR013655; PAS_fold_3. 
Pfam
 PF00010; HLH
 PF00989; PAS
 PF08447; PAS_3 
SMART
 SM00353; HLH
 SM00086; PAC
 SM00091; PAS 
PROSITE
 PS50888; BHLH
 PS50113; PAC
 PS50112; PAS 
PRINTS