UniProt Accession

 RBX2_HUMAN; Q9UBF6; A8K1H9; A8MTB5; C9JYL3; D3DNF7; D3DNF8; Q9BXN8; Q9Y5M7 

Genbank Protein ID

 AF164679; AF142060; AF092878; AF312226; BT007348; AK289894; DB272382; AC112771; CH471052; CH471052; CH471052; CH471052; CH471052; BC005966; BC008627 

Genbank Nucleotide ID

 AAD55984.1; AAD30147.1; AAD25962.1; AAK37450.1; AAP36012.1; BAF82583.1; EAW78991.1; EAW78992.1; EAW78994.1; EAW78995.1; EAW78996.1; AAH05966.1; AAH08627.1 

Protein Name

 RING-box protein 2 

Protein Synonyms/Alias

 Rbx2; CKII beta-binding protein 1; CKBBP1; RING finger protein 7; Regulator of cullins 2; Sensitive to apoptosis gene protein 

Gene Name

 RNF7 

Gene Synonyms/Alias

 RBX2; ROC2; SAG 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
23	HSGSSGSKSGGDKMF	ubiquitination	[1]
28	GSKSGGDKMFSLKKW	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Probable component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. Promotes the neddylation of CUL5 via its interaction with UBE2F. May play a role in protecting cells from apoptosis induced by redox agents. 

Sequence Annotation

 ZN_FING 61 103 RING-type.
 METAL 50 50 Zinc 1 (By similarity).
 METAL 53 53 Zinc 1 (By similarity).
 METAL 61 61 Zinc 3 (By similarity).
 METAL 64 64 Zinc 3 (By similarity).
 METAL 73 73 Zinc 3 (By similarity).
 METAL 80 80 Zinc 2 (By similarity).
 METAL 82 82 Zinc 2 (By similarity).
 METAL 85 85 Zinc 1 (By similarity).
 METAL 87 87 Zinc 3 (By similarity).
 METAL 88 88 Zinc 1 (By similarity).
 METAL 99 99 Zinc 2 (By similarity).
 METAL 102 102 Zinc 2 (By similarity).
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 10 10 Phosphothreonine; by CK2.  

Keyword

 3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Ubl conjugation pathway; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 113 AA 

Protein Sequence

Gene Ontology

 GO:0031466; C:Cul5-RING ubiquitin ligase complex; IDA:MGI.
 GO:0005737; C:cytoplasm; NAS:UniProtKB.
 GO:0005634; C:nucleus; NAS:UniProtKB.
 GO:0005507; F:copper ion binding; TAS:ProtInc.
 GO:0019788; F:NEDD8 ligase activity; IDA:UniProtKB.
 GO:0008270; F:zinc ion binding; TAS:ProtInc.
 GO:0008631; P:intrinsic apoptotic signaling pathway in response to oxidative stress; TAS:ProtInc.
 GO:0043066; P:negative regulation of apoptotic process; TAS:ProtInc.
 GO:0045116; P:protein neddylation; IDA:UniProtKB.
 GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
 GO:0051775; P:response to redox state; TAS:ProtInc. 

Interpro

 IPR001841; Znf_RING.
 IPR013083; Znf_RING/FYVE/PHD.
 IPR024766; Znf_RING_H2. 

Pfam

 PF12678; zf-rbx1 

SMART

 SM00184; RING 

PROSITE

 PS50089; ZF_RING_2 

PRINTS