UniProt Accession

 ISK13_HUMAN; Q1W4C9; A1A4Y2 

Genbank Protein ID

 DQ438947; CH471062; BC128163; BC128164 

Genbank Nucleotide ID

 ABD96086.1; EAW61812.1; AAI28164.1; AAI28165.1 

Protein Name

 Serine protease inhibitor Kazal-type 13 

Protein Synonyms/Alias

 Hepatitis B virus DNA polymerase transactivated serine protease inhibitor; Hespintor; Serine protease inhibitor Kazal-type 5-like 3 

Gene Name

 SPINK13 

Gene Synonyms/Alias

 HBVDNAPTP1; SPINK5L3 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
89	HYRIKFEKYGKCD**	ubiquitination	[1]

Reference

 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 

Functional Description

 May be a serine protease inhibitor (By similarity). Essential for sperm maturation and fertility. Inhibits sperm acrosome reaction, protecting sperm from premature reaction (By similarity). 

Sequence Annotation

 DOMAIN 33 94 Kazal-like.
 CARBOHYD 55 55 N-linked (GlcNAc...) (Potential).
 DISULFID 39 75 By similarity.
 DISULFID 53 72 By similarity.
 DISULFID 61 93 By similarity.  

Keyword

 Alternative splicing; Complete proteome; Disulfide bond; Glycoprotein; Protease inhibitor; Reference proteome; Secreted; Serine protease inhibitor; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 94 AA 

Protein Sequence

Gene Ontology

 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
 GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW. 

Interpro

 IPR002350; Kazal_dom. 

Pfam

 PF00050; Kazal_1 

SMART

 SM00280; KAZAL 

PROSITE

 PS51465; KAZAL_2 

PRINTS