UniProt Accession

 DSBA_ECOLI; P0AEG4; P24991; Q2M8F8; Q46951; Q46952 

Genbank Protein ID

 X80762; M77746; X63186; L19201; U00096; AP009048; U35817; U35818; U35819; U35820; U35821; U35822; U35823; U35824; U35825; U36828; U36829; U36830; U36831; U36832; U36833; U36834; U36835; U35662 

Genbank Nucleotide ID

 CAA56736.1; AAA23715.1; CAA44868.1; AAB02995.1; AAC76858.1; BAE77448.1; AAC43519.1; AAC43520.1; AAC43521.1; AAC43522.1; AAC43523.1; AAC43524.1; AAC43525.1; AAC43526.1; AAC43527.1; AAC43528.1; AAC43529.1; AAC43530.1; AAC43531.1; AAC43532.1; AAC43533.1; AAC43534.1; AAC43535.1; AAA82614.1 

Protein Name

 Thiol:disulfide interchange protein DsbA 

Protein Synonyms/Alias

  

Gene Name

 dsbA 

Gene Synonyms/Alias

 dsf; ppfA; b3860; JW3832 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
77	PEGVKMTKYHVNFMG	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Required for disulfide bond formation in some periplasmic proteins such as PhoA or OmpA. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbA is reoxidized by DsbB. It is required for pilus biogenesis. 

Sequence Annotation

 DOMAIN 20 150 Thioredoxin.
 DISULFID 49 52 Redox-active.  

Keyword

 3D-structure; Complete proteome; Direct protein sequencing; Disulfide bond; Periplasm; Redox-active center; Reference proteome; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 208 AA 

Protein Sequence

Gene Ontology

 GO:0030288; C:outer membrane-bounded periplasmic space; IDA:EcoCyc.
 GO:0003756; F:protein disulfide isomerase activity; IDA:EcoliWiki.
 GO:0015035; F:protein disulfide oxidoreductase activity; IDA:EcoCyc.
 GO:0045454; P:cell redox homeostasis; IEA:InterPro.
 GO:0071236; P:cellular response to antibiotic; IMP:EcoliWiki. 

Interpro

 IPR001853; DSBA-like_thioredoxin_dom.
 IPR023205; Thiol:disulphide_interchange.
 IPR012336; Thioredoxin-like_fold.
 IPR017937; Thioredoxin_CS. 

Pfam

 PF01323; DSBA 

SMART

  

PROSITE

 PS00194; THIOREDOXIN_1
 PS51352; THIOREDOXIN_2 

PRINTS