| Tag | Content |
|---|
| CPLM ID | CPLM-016669 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Fructose-2,6-bisphosphatase TIGAR |
Protein Synonyms/Alias | TP53-induced glycolysis and apoptosis regulator |
Gene Name | Tigar |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 174 | AEVFPVGKHGSLGAN | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Fructose-bisphosphatase hydrolyzing fructose-2,6- bisphosphate as well as fructose-1,6-bisphosphate. Inhibits glycolysis by reducing cellular levels of fructose-2,6- bisphosphate. May protect cells against reactive oxygen species and against apoptosis induced by tp53 (By similarity). |
Sequence Annotation | ACT_SITE 11 11 Tele-phosphohistidine intermediate (By
ACT_SITE 198 198 By similarity. |
Keyword | Complete proteome; Hydrolase; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 269 AA |
Protein Sequence | MPRFALTVIR HGETRLNKEK IIQGQGVDAP LSETGFRQAA AAGQFLSNVQ FTHAFSSDLT 60
RTKQTIHGIL EKSRFCKDMA VKYDSRLRER MYGVAEGKPL SELRAMAKAA GEECPMFTPP 120
GGETVEQVKM RGKDFFDFIC QLILGKAGQR ESVLPGAPGS GLESSLAEVF PVGKHGSLGA 180
NPKGGTLGLA ASILVVSHGA YMRSLFGYFL SDLRCSLPGA RDKLELSSIT PNTGISVFII 240
DCEEARQPSI QCVCMNLQEH LNGVTEKQH 269 |
Gene Ontology | GO:0005622; C:intracellular; IEA:Compara. GO:0004331; F:fructose-2,6-bisphosphate 2-phosphatase activity; IEA:EC. GO:1901525; P:negative regulation of macromitophagy; IMP:MGI. GO:2000378; P:negative regulation of reactive oxygen species metabolic process; IMP:MGI. GO:0010666; P:positive regulation of cardiac muscle cell apoptotic process; IMP:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |