CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-035292
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Serine/threonine-protein kinase WNK1 
Protein Synonyms/Alias
  
Gene Name
 Wnk1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
1372HEKTSRPKLRILNVSacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2633 AA 
Protein Sequence
MSDGTAEKQS GTPGFLSPPA PVPKNGSSSD SSVGEKLGAA VADSGIGRTE EYRRRRHTMD 60
KDSRGAAATT PTEHRFFRRS VICDSNATAL ELPGLPLSIP QPSVPAVVPQ SAPPEPHREE 120
TLTATVASQV SQQPSAAASP GEQAVVGSAT ATVPSSTSKD RPVSQPSLVG SKEEPPPSRS 180
GSGSGGASAK EPQEERNQQQ DDIEELETKA VGMSNDGRFL KFDIEIGRGS FKTVYKGLDT 240
ETTVEVAWCE LQDRKLTKSE RQRFKEEAEM LKGLQHPNIV RFYDSWESTV KGKKCIVLVT 300
ELMTSGTLKT YLKRFKVMKI KVLRSWCRQI LKGLQFLHTR TPPIIHRDLK CDNIFITGPT 360
GSVKIGDLGL ATLKRASFAK SVIGTPEFMA PEMYEEKYDE SVDVYAFGMC MLEMATSEYP 420
YSECQNAAQI YRRVTSGVKP ASFDKVAIPE VKEIIEGCIR QNKDERYSIK DLLNHAFFQE 480
ETGVRVELAE EDDGEKIAIK LWLRIEDIKK LKGKYKDNEA IEFSFDLERD VPEDVAQEMV 540
ESGYVCEGDH KTMAKAIKDR VSLIKRKREQ RQLVREEQEK RKQEESSFKQ QNEQQASVSQ 600
AGIQPLSVAS TGIPTAPTTS ASVSTQVEPE EPEADQHQQL QYQQPSISVL SDGTVDSGQG 660
SSVFTESRVS SQQTVSYGSQ HEQAHSIGTA PGHTVSSIQA QSQPHGVYPP SSMPQSVAHP 720
CGGTPTYPES QIFFPTIHER PVSFSPPPTC PPKVAISQRR KSTSFLEAQT RHFQPLLRTV 780
GQNHLPPGGS PTNWTPEAIV MLGTTANRVN RELCEMQVQP VFETTQIYSD YRPGLVLAEE 840
AHYFIPQETV YLAGVHYQAH AAGQYEGISY NSPVLSSPMK QITEQKPVPG CPASSSVFEF 900
PSGQAFLVGH LQNLRLDSGP SPASPLSSIS APNSTDATHL KFHPVFVPHS APAVLTHSNE 960
NRSNCVFEFH AQTPSSSSGE GGGILPQRVY RNRQVAVDSS QEELSPQSVG LHCHLQPVTE 1020
EQRNNHTPEL TISVVEPMGQ NWPVGSPEYS SDSSQITSSD ISDFQSPPPT GGTAAPFGSD 1080
VSLPYIRLPQ TVLQESPLFF CFPQGTTSQQ VLSASYSSGG SALHPQAQGQ NQGQPSSSLA 1140
GVLSSQPVQH PQQQGIQPTV PPQQAVQYSL PQAASSSEGT VQPVSQPQVS AGTQGFPSRL 1200
PPQYPGDSNI APSSNVASVC IHSTVLAPPP MPTEALATQG YFPTVVQPYV ESTPLVPMGS 1260
VGGQVQVSQP AVSLSQQPPT TSSQQAVLES STQGVSQAAP PEQTPITQSQ PTQPVPLVSS 1320
VDSAHSDVAS GMSDGNENAP SSSGRHEGRT TKRHYRKSVR SRSRHEKTSR PKLRILNVSN 1380
KGDRVVECQL ETHNRKMVTF KFDLDGDNPE EIATIMVNND FILAIERESF VAQVREIIEK 1440
ADEMLSEDVS VEPEGDQGLE SLQGKDDYGF PGSQKLEGEF KQPIAVSSMP QQIGVPTSSL 1500
TQVVHSAGRR FIVSPVPESR LRESKIFTSE IPDPVAASTS QGPGMNLSHS ASSLSLQQAF 1560
SELKHGQMTE GPNTAPPNFN HPGPTFSPFL TSIAGVQTVA ASTPSVSVPI TSSPLNDIST 1620
SVMQSEGALP TDKGIGGVTT STGVVASGGL TTLSVSETPT LSSAVSSSTA PAVVTVSTTS 1680
QPVQASTSGS IASSTGSFPS GTFSTTTGTT VSSVAVPNAK PPTVLLQQVA GNTAGVAIVT 1740
SVSTTTPFPA MASQPSLPLG SSTSAPTLAE TVVVSAHSLD KASHSSTAGL GLSFCAPSSS 1800
SSSGTAVSSS VSQPGIVHPL VISSAIASTP VLPQPAVPTS TPLLPQVPNI PPLVQPVANV 1860
PAVQQTLIHS QPQPALLPNQ PHTHCPEMDA DTQSKAPGID DIKTLEEKLR SLFSEHSSSG 1920
TQHASVSLET PLVVETVTPG IPTTAVAPSK LMTSTTSTCL PPTNLPLGTA GMPVMPVGTP 1980
GQVSTPGTHA SAPASTATGA KPGTTPPKPS LTKTVVPPVG TELSAGTVPC EQLPPFPGPS 2040
LIQTQQPLED LDAQLRRTLS PETIPVTPAV GPLSTMSSTA VTEAGSQPQK DGTEVHVTAS 2100
SSGAGVVKMG RFQVSVTMDD AQKERKNRSE DTKSVHFESS TSESSVLSSS SPESTLVKPE 2160
PNGITVSGIS LDVPDSTHRT PTPEAKSETG QPTKVGRFQV TTTANKVGRF SVSRTEDKVT 2220
ELKKEGPVTS PFRDSEQTVI PAAIPKKEKP ELAEPSHLNG PSSDLEAAFL SRGGEDGSGS 2280
PHSPPHLCSK SLPIQTLSQS LSNSFNSSYM SSDNESDIED EDLRLELRRL REKHLKEIQD 2340
LQSRQKHEIE SLYTKLGKVP PAVIIPPAAP LSGRRRRPTK SKGSKSSRSS SLGNKSPQLS 2400
GNLSGQSGTS VLNPQQTLHP PGNTPETGHN QLLQPLKPSP SSDNLYSAFT SDGAISVPSL 2460
SAPGQGTSST NTVGGTVSSQ AAQAQPPAMT SSRKGTFTDD LHKLVDNWAR DAMNLSGRRG 2520
SKGHMNYEGP GMARKFSAPG QLCISMTSNM GGSTPISAAS ATSLGHFTKS MCPPQQYGFP 2580
AAPFGTQWSG TGGPAPQPLG QFQPVGTTSL QNFNISNLQK SISNPPGSNL RTT 2633 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro. 
Interpro
 IPR011009; Kinase-like_dom.
 IPR024678; Kinase_OSR1/WNK_CCT.
 IPR000719; Prot_kinase_cat_dom.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF12202; OSR1_C
 PF00069; Pkinase 
SMART
  
PROSITE
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS