| Tag | Content |
|---|
| CPLM ID | CPLM-015562 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Ras association domain-containing protein 6 |
Protein Synonyms/Alias | |
Gene Name | RASSF6 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 170 | SYHSNTLKPHAKDEP | ubiquitination | [1] |
|
Reference | [1] Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP. Mol Cell. 2011 Oct 21;44(2):325-40. [ PMID: 21906983] |
Functional Description | Involved in the induction of apoptosis, through both caspase-dependent and caspase-independent pathways. May act as a Ras effector protein. May suppress the serum-induced basal levels of NF-kappa-B (By similarity). |
Sequence Annotation | DOMAIN 218 306 Ras-associating.
DOMAIN 313 360 SARAH. |
Keyword | Alternative splicing; Apoptosis; Complete proteome; Polymorphism; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 369 AA |
Protein Sequence | MLWEETGAAP APARASDLPY RISSDHLKKE EKMTMMAHQY PSWIFINEKT FITREQLNSL 60
LKTYNIFYEN QKNLHILYGE TEDGKLIVEG MLDIFWGVKR PIQLKIQDEK PFSSFTSMKS 120
SDVFSSKGMT RWGEFDDLYR ISELDRTQIP MSEKRNSQED YLSYHSNTLK PHAKDEPDSP 180
VLYRTMSEAA LVRKRMKPLM MDRKERQKNR ASINGHFYNH ETSIFIPAFE SETKVRVNSN 240
MRTEEVIKQL LQKFKIENSP QDFALHIIFA TGEQRRLKKT DIPLLQRLLQ GPSEKNARIF 300
LMDKDAEEIS SDVAQYINFH FSLLESILQR LNEEEKREIQ RIVTKFNKEK AIILKCLQNK 360
LVIKTETTV 369 |
Gene Ontology | GO:0006915; P:apoptotic process; IEA:UniProtKB-KW. GO:0042981; P:regulation of apoptotic process; IEA:Compara. GO:0007165; P:signal transduction; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |