CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007487
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Eukaryotic translation initiation factor 2 subunit 1 
Protein Synonyms/Alias
 Eukaryotic translation initiation factor 2 subunit alpha; eIF-2-alpha 
Gene Name
 eIF-2alpha 
Gene Synonyms/Alias
 eIF2a; CG9946 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
60RRIRSINKLIRVGKTacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
 eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This preinitiation complex mediates ribosomal recognition of a start codon during the scanning process of the leader region. 
Sequence Annotation
 DOMAIN 16 87 S1 motif.
 MOD_RES 51 51 Phosphoserine (By similarity).  
Keyword
 Complete proteome; Initiation factor; Phosphoprotein; Protein biosynthesis; Reference proteome; RNA-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 341 AA 
Protein Sequence
MALTSRFYNE RYPEIEDVVM VNVLSIAEMG AYVHLLEYNN IEGMILLSEL SRRRIRSINK 60
LIRVGKTEPV VVIRVDKEKG YIDLSKRRVS PEDVEKCTER FAKAKAINSL LRHVADILGF 120
EGNEKLEDLY QKTAWHFEKK YNNKTVAYDI FKQSVTDPTV FDECNLEPET KEVLLSNIKR 180
KLVSPTVKIR ADIECSCYGY EGIDAVKASL TKGLELSTEE LPIRINLIAP PLYVMTTSTT 240
KKTDGLKALE VAIEHIRAKT SEYDGEFKVI MAPKLVTAID EADLARRLER AEAENAQVAG 300
DDDEEDGADQ EGMQFDPEKE FNHKGSGAGR ANEEDEEEEE D 341 
Gene Ontology
 GO:0005829; C:cytosol; ISS:FlyBase.
 GO:0005850; C:eukaryotic translation initiation factor 2 complex; ISS:FlyBase.
 GO:0005851; C:eukaryotic translation initiation factor 2B complex; ISS:FlyBase.
 GO:0005875; C:microtubule associated complex; IDA:FlyBase.
 GO:0003743; F:translation initiation factor activity; ISS:FlyBase.
 GO:0000022; P:mitotic spindle elongation; IMP:FlyBase. 
Interpro
 IPR012340; NA-bd_OB-fold.
 IPR003029; Rbsml_prot_S1_RNA-bd_dom.
 IPR022967; RNA-binding_domain_S1.
 IPR024055; TIF2_asu_C.
 IPR024054; TIF2_asu_middle.
 IPR011488; TIF_2_asu. 
Pfam
 PF07541; EIF_2_alpha
 PF00575; S1 
SMART
 SM00316; S1 
PROSITE
 PS50126; S1 
PRINTS