| Tag | Content |
|---|
| CPLM ID | CPLM-013248 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | UBX domain-containing protein 1 |
Protein Synonyms/Alias | SAPK substrate protein 1 |
Gene Name | Ubxn1 |
Gene Synonyms/Alias | Saks1 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 137 | ELSAARQKLQEDEIR | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Ubiquitin-binding protein that interacts with the BRCA1- BARD1 heterodimer, and regulates its activity. Specifically binds 'Lys-6'-linked polyubiquitin chains. Interaction with autoubiquitinated BRCA1, leads to inhibit the E3 ubiquitin-protein ligase activity of the BRCA1-BARD1 heterodimer. Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol (By similarity). |
Sequence Annotation | DOMAIN 1 42 UBA.
DOMAIN 209 291 UBX.
REGION 43 297 Interaction with BRCA1 (By similarity).
MOD_RES 2 2 N-acetylalanine (By similarity).
MOD_RES 187 187 Phosphoserine (By similarity).
MOD_RES 192 192 Phosphothreonine (By similarity).
MOD_RES 199 199 Phosphoserine (By similarity).
MOD_RES 200 200 Phosphoserine; by MAPK12 (By similarity).
MOD_RES 270 270 Phosphoserine (By similarity). |
Keyword | Acetylation; Coiled coil; Complete proteome; Cytoplasm; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 297 AA |
Protein Sequence | MAELTALESL IEMGFPRGRA EKALALTGNQ GIEAAMDWLM EHEDDPDVDE PLETPLSHIL 60
GREPTPSEQV GPEGSGSAAG ESKPVLTEEE RQEQTKRMLE LVAQKQRERE EREEREALER 120
EKQRRRQGQE LSAARQKLQE DEIRRAAEER RREKAEELAA RQRVREKIER DKAERAQKYG 180
GTVGSRSSPP ATDPGPVPSS PRQEPPTKRE YDQCRIQVRL PDGTSLTQTF RAREQLAAVR 240
LYVELHRGEE PGQDQDPVQL LSGFPRRAFS EADMERPLQE LGLVPSAVLI VAKKCPS 297 |
Gene Ontology | GO:0034098; C:Cdc48p-Npl4p-Ufd1p AAA ATPase complex; IEA:Compara. GO:0005737; C:cytoplasm; IDA:RGD. GO:0030425; C:dendrite; IDA:RGD. GO:0043025; C:neuronal cell body; IDA:RGD. GO:0005634; C:nucleus; IDA:RGD. GO:0000502; C:proteasome complex; IEA:Compara. GO:0071796; F:K6-linked polyubiquitin binding; ISS:UniProtKB. GO:0032435; P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process; ISS:UniProtKB. GO:0031397; P:negative regulation of protein ubiquitination; ISS:UniProtKB. |
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Pfam | |
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PROSITE | |
PRINTS | |