CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010085
UniProt Accession
Genbank Protein ID
 U00089 
Genbank Nucleotide ID
Protein Name
 Chaperone protein DnaK 
Protein Synonyms/Alias
 HSP70; Heat shock 70 kDa protein; Heat shock protein 70 
Gene Name
 dnaK 
Gene Synonyms/Alias
 hsp70; MPN_434; MP407 
Created Date
 July 27, 2013 
Organism
 Mycoplasma pneumoniae (strain ATCC 29342 / M129) 
NCBI Taxa ID
 272634 
Lysine Modification
Position
Peptide
Type
References
84TSNKVTVKNPDGSTKacetylation[1]
91KNPDGSTKELTPEEVacetylation[1]
112YLKDYAEKKIGKTISacetylation[1]
142NATKTAGKIAGLNVEacetylation[1]
166ALAYGIDKSNREMKVacetylation[1]
279GPVNVELKLTRAKFEacetylation[1]
284ELKLTRAKFEEITKQacetylation[1]
290AKFEEITKQLLERTRacetylation[1]
308SDVLREAKIKPEEINacetylation[1]
310VLREAKIKPEEINEIacetylation[1]
331TRMPAVQKLVESMVPacetylation[1]
504IRDAEANKERDNVIRacetylation[1]
528ESIVSTIKEILQSPEacetylation[1]
537ILQSPEAKDFPKEEKacetylation[1]
541PEAKDFPKEEKEKLDacetylation[1]
549EEKEKLDKITGGIDAacetylation[1]
565IKANDYTKLKAEIENacetylation[1]
567ANDYTKLKAEIENFKacetylation[1]
574KAEIENFKKWREEMAacetylation[1]
Reference
 [1] Cross-talk between phosphorylation and lysine acetylation in a genome-reduced bacterium.
 van Noort V, Seebacher J, Bader S, Mohammed S, Vonkova I, Betts MJ, Kühner S, Kumar R, Maier T, O'Flaherty M, Rybin V, Schmeisky A, Yus E, Stülke J, Serrano L, Russell RB, Heck AJ, Bork P, Gavin AC.
 Mol Syst Biol. 2012 Feb 28;8:571. [PMID: 22373819] 
Functional Description
 Acts as a chaperone (By similarity). 
Sequence Annotation
 MOD_RES 182 182 Phosphothreonine; by autocatalysis (By  
Keyword
 ATP-binding; Chaperone; Complete proteome; Nucleotide-binding; Phosphoprotein; Reference proteome; Stress response. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 595 AA 
Protein Sequence
MSTDNGLIIG IDLGTTNSCV SVMENGRPVV LENPEGKRTT PSIVSYKNNE IIVGDAAKRQ 60
MVTNPNTIVS IKRLMGTSNK VTVKNPDGST KELTPEEVSA QILSYLKDYA EKKIGKTISR 120
AVITVPAYFN DAERNATKTA GKIAGLNVER IINEPTAAAL AYGIDKSNRE MKVLVYDLGG 180
GTFDVSLLDI AEGTFEVLAT AGDNRLGGDD WDNKIIEFIL AHIAQEHNGL NLSNDKMAMQ 240
RLKEAAERAK IELSAQLEAI ISLPFLTVTE KGPVNVELKL TRAKFEEITK QLLERTRNPI 300
SDVLREAKIK PEEINEILLV GGSTRMPAVQ KLVESMVPGH SPNRSINPDE VVAIGAAIQG 360
GVLRGDVKDV LLLDVTPLTL SIETLGGVAT PLIKRNTTIP VSKSQIFSTA QDNQESVDVV 420
VCQGERPMAR DNKSLGRFNL GGIQPAPKGK PQIEITFSLD ANGILNVKAK DLTTQKENSI 480
TISDNGNLSE EEIQKMIRDA EANKERDNVI RERIELRNEG ESIVSTIKEI LQSPEAKDFP 540
KEEKEKLDKI TGGIDAAIKA NDYTKLKAEI ENFKKWREEM AKKYNPNGDQ GQPAQ 595 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:HAMAP.
 GO:0006457; P:protein folding; IEA:InterPro.
 GO:0006950; P:response to stress; IEA:UniProtKB-KW. 
Interpro
 IPR012725; Chaperone_DnaK.
 IPR018181; Heat_shock_70_CS.
 IPR013126; Hsp_70_fam. 
Pfam
 PF00012; HSP70 
SMART
  
PROSITE
 PS00297; HSP70_1
 PS00329; HSP70_2
 PS01036; HSP70_3 
PRINTS
 PR00301; HEATSHOCK70.