UniProt Accession

 SIR7_HUMAN; Q9NRC8; A8K2K0; B3KSU8; Q3MIK4; Q9NSZ6; Q9NUS6 

Genbank Protein ID

 AF233395; AK002027; AK094326; AK290265; AC145207; BC017305; BC101791; BC101793; AL137626 

Genbank Nucleotide ID

 AAF43431.1; BAA92044.1; BAG52860.1; BAF82954.1; AAH17305.1; AAI01792.1; AAI01794.1; CAB70848.2 

Protein Name

 NAD-dependent protein deacetylase sirtuin-7 

Protein Synonyms/Alias

 Regulatory protein SIR2 homolog 7; SIR2-like protein 7 

Gene Name

 SIRT7 

Gene Synonyms/Alias

 SIR2L7 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
131	GVWTLLQKGRSVSAA	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 NAD-dependent protein deacetylase that specifically mediates deacetylation of histone H3 at 'Lys-18' (H3K18Ac). In contrast to other histone deacetylases, displays selectivity for a single histone mark, H3K18Ac, directly linked to control of gene expression. H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors. SIRT7 thereby acts as a transcription repressor. Moreover, H3K18 hypoacetylation has been reported as a marker of malignancy in various cancers and seems to maintain the transformed phenotype of cancer cells. These data suggest that SIRT7 may play a key role in oncogenic transformation by suppresses expression of tumor suppressor genes by locus-specific deacetylation of H3K18Ac at promoter regions. Also required to restore the transcription of ribosomal RNA (rRNA) at the exit from mitosis: promotes the association of RNA polymerase I with the rDNA promoter region and coding region. Stimulates transcription activity of the RNA polymerase I complex. May also deacetylate p53/TP53 and promotes cell survival, however such data need additional confirmation. 

Sequence Annotation

 DOMAIN 90 331 Deacetylase sirtuin-type.
 NP_BIND 107 126 NAD (By similarity).
 NP_BIND 167 170 NAD (By similarity).
 NP_BIND 268 270 NAD (By similarity).
 NP_BIND 297 299 NAD (By similarity).
 ACT_SITE 187 187 Proton acceptor.
 METAL 195 195 Zinc (By similarity).
 METAL 198 198 Zinc (By similarity).
 METAL 225 225 Zinc (By similarity).
 METAL 228 228 Zinc (By similarity).
 BINDING 315 315 NAD; via amide nitrogen (By similarity).  

Keyword

 Alternative splicing; Chromatin regulator; Complete proteome; Cytoplasm; Hydrolase; Metal-binding; NAD; Nucleus; Phosphoprotein; Reference proteome; Repressor; Transcription; Transcription regulation; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 400 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005731; C:nucleolus organizer region; IDA:UniProtKB.
 GO:0003682; F:chromatin binding; IDA:UniProtKB.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0070403; F:NAD+ binding; IEA:InterPro.
 GO:0097372; F:NAD-dependent histone deacetylase activity (H3-K18 specific); IDA:UniProtKB.
 GO:0070932; P:histone H3 deacetylation; IDA:UniProtKB.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
 GO:0007072; P:positive regulation of transcription on exit from mitosis; IMP:UniProtKB.
 GO:0009303; P:rRNA transcription; IMP:UniProtKB. 

Interpro

 IPR003000; Sirtuin.
 IPR026590; Ssirtuin_cat_dom. 

Pfam

 PF02146; SIR2 

SMART

  

PROSITE

 PS50305; SIRTUIN 

PRINTS