UniProt Accession

 CXB1_HUMAN; P08034; B2R8R2; D3DVV2; Q5U0S4 

Genbank Protein ID

 X04325; AK313474; BT019329; CH471132; CH471132; BC002805; BC022426; BC039198; L47127 

Genbank Nucleotide ID

 CAA27856.1; BAG36259.1; AAV38136.1; EAX05305.1; EAX05306.1; AAH02805.1; AAH22426.1; AAH39198.1; AAA75086.1 

Protein Name

 Gap junction beta-1 protein 

Protein Synonyms/Alias

 Connexin-32; Cx32; GAP junction 28 kDa liver protein 

Gene Name

 GJB1 

Gene Synonyms/Alias

 CX32 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
260	SEQDGSLKDILRRSP	ubiquitination	[1]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 

Functional Description

 One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. 

Sequence Annotation

 MOD_RES 258 258 Phosphoserine (By similarity).
 MOD_RES 266 266 Phosphoserine (By similarity).  

Keyword

 3D-structure; Cell junction; Cell membrane; Charcot-Marie-Tooth disease; Complete proteome; Dejerine-Sottas syndrome; Disease mutation; Gap junction; Membrane; Neuropathy; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 283 AA 

Protein Sequence

Gene Ontology

 GO:0005922; C:connexon complex; TAS:ProtInc.
 GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005243; F:gap junction channel activity; IEA:Compara.
 GO:0007267; P:cell-cell signaling; TAS:ProtInc.
 GO:0016044; P:cellular membrane organization; TAS:Reactome.
 GO:0016264; P:gap junction assembly; TAS:Reactome.
 GO:0007399; P:nervous system development; TAS:ProtInc.
 GO:0051259; P:protein oligomerization; IEA:Compara.
 GO:0015868; P:purine ribonucleotide transport; IEA:Compara.
 GO:0006810; P:transport; TAS:ProtInc. 

Interpro

 IPR000500; Connexin.
 IPR002267; Connexin32.
 IPR019570; Connexin_CCC.
 IPR017990; Connexin_CS.
 IPR013092; Connexin_N. 

Pfam

 PF00029; Connexin
 PF10582; Connexin_CCC 

SMART

 SM00037; CNX
 SM01089; Connexin_CCC 

PROSITE

 PS00407; CONNEXINS_1
 PS00408; CONNEXINS_2 

PRINTS

 PR00206; CONNEXIN.
 PR01138; CONNEXINB1.