CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016297
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Calcium uptake protein 3, mitochondrial 
Protein Synonyms/Alias
 EF-hand domain-containing family member A2 
Gene Name
 MICU3 
Gene Synonyms/Alias
 EFHA2 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
184PKVAKTWKSLSKQELacetylation[1]
188KTWKSLSKQELNQMLacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 May play a role in mitochondrial calcium uptake (By similarity). 
Sequence Annotation
 DOMAIN 232 267 EF-hand 1.
 DOMAIN 401 436 EF-hand 2.
 DOMAIN 470 505 EF-hand 3.  
Keyword
 Calcium; Complete proteome; Membrane; Metal-binding; Mitochondrion; Reference proteome; Repeat; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 530 AA 
Protein Sequence
MAALRRLLWP PPRVSPPLCA HQPLLGPWGR PAVTTLGLPG RPFSSREDEE RAVAEAAWRR 60
RRRWGELSVA AAAGGGLVGL VCYQLYGDPR AGSPATGRPS KSAATEPEDP PRGRGMLPIP 120
VAAAKETVAI GRTDIEDLDL YATSRERRFR LFASIECEGQ LFMTPYDFIL AVTTDEPKVA 180
KTWKSLSKQE LNQMLAETPP VWKGSSKLFR NLKEKGVISY TEYLFLLCIL TKPHAGFRIA 240
FNMFDTDGNE MVDKKEFLVL QEIFRKKNEK REIKGDEEKR AMLRLQLYGY HSPTNSVLKT 300
DAEELVSRSY WDTLRRNTSQ ALFSDLAERA DDITSLVTDT TLLVHFFGKK GKAELNFEDF 360
YRFMDNLQTE VLEIEFLSYS NGMNTISEED FAHILLRYTN VENTSVFLEN VRYSIPEEKG 420
ITFDEFRSFF QFLNNLEDFA IALNMYNFAS RSIGQDEFKR AVYVATGLKF SPHLVNTVFK 480
IFDVDKDDQL SYKEFIGIMK DRLHRGFRGY KTVQKYPTFK SCLKKELHSR 530 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
 GO:0005509; F:calcium ion binding; IEA:InterPro. 
Interpro
 IPR011992; EF-hand-like_dom.
 IPR018247; EF_Hand_1_Ca_BS.
 IPR002048; EF_hand_dom. 
Pfam
  
SMART
 SM00054; EFh 
PROSITE
 PS00018; EF_HAND_1
 PS50222; EF_HAND_2 
PRINTS