UniProt Accession

 B4DDY8_HUMAN; B4DDY8 

Genbank Protein ID

 AC116353; AK293390; CH471062 

Genbank Nucleotide ID

 BAG56899.1; EAW62019.1 

Protein Name

 Histidyl-tRNA synthetase-like, isoform CRA_a 

Protein Synonyms/Alias

 Probable histidine--tRNA ligase, mitochondrial; cDNA FLJ50406, highly similar to Histidyl-tRNA synthetase homolog (EC 6.1.1.21) 

Gene Name

 HARS2 

Gene Synonyms/Alias

 HARSL; hCG_1982406 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
94	SGLMYDLKDQGGELL	ubiquitination	[1]
394	VFVATPQKNFLQERL	ubiquitination	[1]
419	IKAEMLYKNNPKLLT	acetylation	[2, 3]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

  

Sequence Annotation

  

Keyword

 Aminoacyl-tRNA synthetase; Complete proteome; Ligase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 481 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0004821; F:histidine-tRNA ligase activity; IEA:InterPro.
 GO:0006427; P:histidyl-tRNA aminoacylation; IEA:InterPro. 

Interpro

 IPR006195; aa-tRNA-synth_II.
 IPR004154; Anticodon-bd.
 IPR015807; His-tRNA-ligase.
 IPR004516; HisRS/HisZ. 

Pfam

 PF03129; HGTP_anticodon 

SMART

  

PROSITE

 PS50862; AA_TRNA_LIGASE_II 

PRINTS