Tag | Content |
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CPLM ID | CPLM-000751 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 |
Protein Synonyms/Alias | Complex I-B8; CI-B8; NADH-ubiquinone oxidoreductase B8 subunit |
Gene Name | NDUFA2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
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98 | LENVLSGKA****** | ubiquitination | [1] |
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Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. |
Sequence Annotation | MOD_RES 2 2 N-acetylalanine. MOD_RES 64 64 N6-acetyllysine (By similarity). DISULFID 24 58 Redox-active. |
Keyword | 3D-structure; Acetylation; Alternative splicing; Complete proteome; Disulfide bond; Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane; Polymorphism; Reference proteome; Respiratory chain; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 99 AA |
Protein Sequence | MAAAAASRGV GAKLGLREIR IHLCQRSPGS QGVRDFIEKR YVELKKANPD LPILIRECSD 60 VQPKLWARYA FGQETNVPLN NFSADQVTRA LENVLSGKA 99 |
Gene Ontology | GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB. GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB. GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB. GO:0044281; P:small molecule metabolic process; TAS:Reactome. |
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