UniProt Accession

 YETS4_MOUSE; Q9CR11; Q9CW86 

Genbank Protein ID

 AK002839; AK012096; AK010522; BC020043 

Genbank Nucleotide ID

 BAB22396.1; BAB28027.1; BAB27003.1; AAH20043.1 

Protein Name

 YEATS domain-containing protein 4 

Protein Synonyms/Alias

  

Gene Name

 Yeats4 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
131	DTNAMLGKKTVVSEF	acetylation	[1]

Reference

 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

 Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage (By similarity). 

Sequence Annotation

 DOMAIN 22 126 YEATS.
 REGION 163 227 Interaction with MLLT10 (By similarity).
 REGION 168 227 Interaction with TACC1 (By similarity).  

Keyword

 Chromatin regulator; Coiled coil; Complete proteome; Growth regulation; Nucleus; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 227 AA 

Protein Sequence

Gene Ontology

 GO:0035267; C:NuA4 histone acetyltransferase complex; ISS:UniProtKB.
 GO:0043968; P:histone H2A acetylation; ISS:UniProtKB.
 GO:0043967; P:histone H4 acetylation; ISS:UniProtKB.
 GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR005033; YEATS. 

Pfam

 PF03366; YEATS 

SMART

  

PROSITE

 PS51037; YEATS 

PRINTS