UniProt Accession

 PAOX_MOUSE; Q8C0L6; Q8K254 

Genbank Protein ID

 AF226656; AK030664; BC033913; BC082783 

Genbank Nucleotide ID

 AAN40705.2; BAC27070.1; AAH33913.1; AAH82783.1 

Protein Name

 Peroxisomal N(1)-acetyl-spermine/spermidine oxidase 

Protein Synonyms/Alias

 Polyamine oxidase 

Gene Name

 Paox 

Gene Synonyms/Alias

 Pao 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
231	RILASLPKDTVAFDK	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Flavoenzyme which catalyzes the oxidation of N(1)- acetylspermine to spermidine and is thus involved in the polyamine back-conversion. Can also oxidize N(1)-acetylspermidine to putrescine. Substrate specificity: N(1)-acetylspermine = N(1)- acetylspermidine > N(1),N(12)-diacylspermine >> spermine. Does not oxidize spermidine. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs. 

Sequence Annotation

 MOTIF 502 504 Microbody targeting signal (Potential).  

Keyword

 Alternative splicing; Complete proteome; Cytoplasm; FAD; Flavoprotein; Oxidoreductase; Peroxisome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 504 AA 

Protein Sequence

Gene Ontology

 GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
 GO:0052899; F:N(1),N(12)-diacetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity; IEA:EC.
 GO:0052904; F:N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity; IEA:EC.
 GO:0052903; F:N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity; IEA:EC.
 GO:0046592; F:polyamine oxidase activity; IDA:MGI.
 GO:0052902; F:spermidine:oxygen oxidoreductase (3-aminopropanal-forming) activity; IEA:EC.
 GO:0052901; F:spermine:oxygen oxidoreductase (spermidine-forming) activity; IEA:EC.
 GO:0006598; P:polyamine catabolic process; IDA:MGI.
 GO:1901307; P:positive regulation of spermidine biosynthetic process; IEA:Compara.
 GO:0009446; P:putrescine biosynthetic process; IEA:Compara.
 GO:0009447; P:putrescine catabolic process; IEA:Compara.
 GO:0046203; P:spermidine catabolic process; IEA:Compara.
 GO:0046208; P:spermine catabolic process; IEA:Compara. 

Interpro

 IPR002937; Amino_oxidase.
 IPR016040; NAD(P)-bd_dom. 

Pfam

 PF01593; Amino_oxidase 

SMART

  

PROSITE

  

PRINTS