UniProt Accession

 E9PJI4_HUMAN; E9PJI4 

Genbank Protein ID

 AP001132 

Genbank Nucleotide ID

  

Protein Name

 Serine/threonine-protein kinase Chk1 

Protein Synonyms/Alias

  

Gene Name

 CHEK1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
53	VDCPENIKKEICINK	acetylation	[1]
53	VDCPENIKKEICINK	ubiquitination	[2]
54	DCPENIKKEICINKM	acetylation	[1]
54	DCPENIKKEICINKM	ubiquitination	[2]
60	KKEICINKMLNHENV	ubiquitination	[2]

Reference

 [1] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

  

Sequence Annotation

  

Keyword

 ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 170 AA 

Protein Sequence

Gene Ontology

 GO:0000785; C:chromatin; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0005657; C:replication fork; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0035402; F:histone kinase activity (H3-T11 specific); IEA:Compara.
 GO:0071313; P:cellular response to caffeine; IEA:Compara.
 GO:0048096; P:chromatin-mediated maintenance of transcription; IEA:Compara.
 GO:0006975; P:DNA damage induced protein phosphorylation; IEA:Compara.
 GO:0006281; P:DNA repair; IEA:Compara.
 GO:0031572; P:G2 DNA damage checkpoint; IEA:Compara.
 GO:0000086; P:G2/M transition of mitotic cell cycle; IEA:Compara.
 GO:0035407; P:histone H3-T11 phosphorylation; IEA:GOC.
 GO:0042127; P:regulation of cell proliferation; IEA:Compara.
 GO:2000615; P:regulation of histone H3-K9 acetylation; IEA:Compara.
 GO:0033261; P:regulation of S phase; IEA:Compara.
 GO:0010767; P:regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage; IEA:Compara. 

Interpro

 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR008271; Ser/Thr_kinase_AS. 

Pfam

 PF00069; Pkinase 

SMART

  

PROSITE

 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 

PRINTS