Tag | Content |
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CPLM ID | CPLM-006506 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Myosin-10 |
Protein Synonyms/Alias | Cellular myosin heavy chain, type B; Myosin heavy chain 10; Myosin heavy chain, non-muscle IIb; Non-muscle myosin heavy chain B; NMMHC-B; Non-muscle myosin heavy chain IIb; NMMHC II-b; NMMHC-IIB |
Gene Name | MYH10 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
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83 | IQKMNPPKFSKVEDM | ubiquitination | [1] | 232 | LESFGNAKTVKNDNS | ubiquitination | [1] | 572 | KPRQLKDKADFCIIH | ubiquitination | [1] | 587 | YAGKVDYKADEWLMK | ubiquitination | [1] | 710 | NHEKRAGKLDPHLVL | ubiquitination | [1] | 788 | LYRIGQSKIFFRAGV | ubiquitination | [1] | 838 | QQQLSALKVLQRNCA | ubiquitination | [1] | 1473 | NLEKKQKKFDQLLAE | ubiquitination | [1] | 1505 | EAREKETKALSLARA | ubiquitination | [1] |
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Reference | [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C. Nat Cell Biol. 2012 Oct;14(10):1089-98. [ PMID: 23000965] |
Functional Description | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. |
Sequence Annotation | DOMAIN 2 785 Myosin head-like. DOMAIN 786 815 IQ. NP_BIND 178 185 ATP (Potential). MOD_RES 442 442 N6-acetyllysine. MOD_RES 1145 1145 Phosphoserine. MOD_RES 1645 1645 N6-acetyllysine. MOD_RES 1938 1938 Phosphoserine. MOD_RES 1939 1939 Phosphoserine. MOD_RES 1952 1952 Phosphoserine. MOD_RES 1956 1956 Phosphoserine. |
Keyword | Acetylation; Actin-binding; Alternative splicing; ATP-binding; Calmodulin-binding; Cell shape; Coiled coil; Complete proteome; Motor protein; Myosin; Nucleotide-binding; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1976 AA |
Protein Sequence | MAQRTGLEDP ERYLFVDRAV IYNPATQADW TAKKLVWIPS ERHGFEAASI KEERGDEVMV 60 ELAENGKKAM VNKDDIQKMN PPKFSKVEDM AELTCLNEAS VLHNLKDRYY SGLIYTYSGL 120 FCVVINPYKN LPIYSENIIE MYRGKKRHEM PPHIYAISES AYRCMLQDRE DQSILCTGES 180 GAGKTENTKK VIQYLAHVAS SHKGRKDHNI PGELERQLLQ ANPILESFGN AKTVKNDNSS 240 RFGKFIRINF DVTGYIVGAN IETYLLEKSR AVRQAKDERT FHIFYQLLSG AGEHLKSDLL 300 LEGFNNYRFL SNGYIPIPGQ QDKDNFQETM EAMHIMGFSH EEILSMLKVV SSVLQFGNIS 360 FKKERNTDQA SMPENTVAQK LCHLLGMNVM EFTRAILTPR IKVGRDYVQK AQTKEQADFA 420 VEALAKATYE RLFRWLVHRI NKALDRTKRQ GASFIGILDI AGFEIFELNS FEQLCINYTN 480 EKLQQLFNHT MFILEQEEYQ REGIEWNFID FGLDLQPCID LIERPANPPG VLALLDEECW 540 FPKATDKTFV EKLVQEQGSH SKFQKPRQLK DKADFCIIHY AGKVDYKADE WLMKNMDPLN 600 DNVATLLHQS SDRFVAELWK DEIQNIQRAS FYDSVSGLHE PPVDRIVGLD QVTGMTETAF 660 GSAYKTKKGM FRTVGQLYKE SLTKLMATLR NTNPNFVRCI IPNHEKRAGK LDPHLVLDQL 720 RCNGVLEGIR ICRQGFPNRI VFQEFRQRYE ILTPNAIPKG FMDGKQACER MIRALELDPN 780 LYRIGQSKIF FRAGVLAHLE EERDLKITDI IIFFQAVCRG YLARKAFAKK QQQLSALKVL 840 QRNCAAYLKL RHWQWWRVFT KVKPLLQVTR QEEELQAKDE ELLKVKEKQT KVEGELEEME 900 RKHQQLLEEK NILAEQLQAE TELFAEAEEM RARLAAKKQE LEEILHDLES RVEEEEERNQ 960 ILQNEKKKMQ AHIQDLEEQL DEEEGARQKL QLEKVTAEAK IKKMEEEILL LEDQNSKFIK 1020 EKKLMEDRIA ECSSQLAEEE EKAKNLAKIR NKQEVMISDL EERLKKEEKT RQELEKAKRK 1080 LDGETTDLQD QIAELQAQID ELKLQLAKKE EELQGALARG DDETLHKNNA LKVVRELQAQ 1140 IAELQEDFES EKASRNKAEK QKRDLSEELE ALKTELEDTL DTTAAQQELR TKREQEVAEL 1200 KKALEEETKN HEAQIQDMRQ RHATALEELS EQLEQAKRFK ANLEKNKQGL ETDNKELACE 1260 VKVLQQVKAE SEHKRKKLDA QVQELHAKVS EGDRLRVELA EKASKLQNEL DNVSTLLEEA 1320 EKKGIKFAKD AASLESQLQD TQELLQEETR QKLNLSSRIR QLEEEKNSLQ EQQEEEEEAR 1380 KNLEKQVLAL QSQLADTKKK VDDDLGTIES LEEAKKKLLK DAEALSQRLE EKALAYDKLE 1440 KTKNRLQQEL DDLTVDLDHQ RQVASNLEKK QKKFDQLLAE EKSISARYAE ERDRAEAEAR 1500 EKETKALSLA RALEEALEAK EEFERQNKQL RADMEDLMSS KDDVGKNVHE LEKSKRALEQ 1560 QVEEMRTQLE ELEDELQATE DAKLRLEVNM QAMKAQFERD LQTRDEQNEE KKRLLIKQVR 1620 ELEAELEDER KQRALAVASK KKMEIDLKDL EAQIEAANKA RDEVIKQLRK LQAQMKDYQR 1680 ELEEARASRD EIFAQSKESE KKLKSLEAEI LQLQEELASS ERARRHAEQE RDELADEITN 1740 SASGKSALLD EKRRLEARIA QLEEELEEEQ SNMELLNDRF RKTTLQVDTL NAELAAERSA 1800 AQKSDNARQQ LERQNKELKA KLQELEGAVK SKFKATISAL EAKIGQLEEQ LEQEAKERAA 1860 ANKLVRRTEK KLKEIFMQVE DERRHADQYK EQMEKANARM KQLKRQLEEA EEEATRANAS 1920 RRKLQRELDD ATEANEGLSR EVSTLKNRLR RGGPISFSSS RSGRRQLHLE GASLELSDDD 1980 TESKTSDVNE TQPPQSE 1997 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |