CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020840
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Nitric oxide synthase-interacting protein 
Protein Synonyms/Alias
  
Gene Name
 Nosip 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
78LEYILHQKREIARQVubiquitination[1]
153PSVGPVGKDKDKALPubiquitination[1]
157PVGKDKDKALPSFWIubiquitination[1]
172PSLTPEAKATKLEKPubiquitination[1]
190VTCPMSGKPLRMSDLubiquitination[1]
289GFAGSGVKLQAEMSRubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity (By similarity). 
Sequence Annotation
 REGION 55 75 U-box-like.
 MOTIF 78 101 Nuclear localization signal (By  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; Nucleus; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 301 AA 
Protein Sequence
MTRHGKNCTA GAVYTYHEKK KDTAASGYGT QNIRLSRDAV KDFDCCCLSL QPCHDPVVTP 60
DGYLYEREAI LEYILHQKRE IARQVKAYEK QRGARREEQK ELQRAAAQDQ VRGFLEKEAA 120
IVSRPLNPFM PKAATLPNTE GEQPGPSVGP VGKDKDKALP SFWIPSLTPE AKATKLEKPS 180
RTVTCPMSGK PLRMSDLTSV RFTQLDDSVD RVGLITRSER YVCAVTRDSL SNATPCAVLR 240
PSGAVVTLEC VEKLIRKDMV DPVNGDTLTE RDIIVLQRGG TGFAGSGVKL QAEMSRPVMQ 300
A 301 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0051001; P:negative regulation of nitric-oxide synthase activity; IEA:Compara. 
Interpro
 IPR016818; Nitric_oxide_synth-interacting.
 IPR013083; Znf_RING/FYVE/PHD. 
Pfam
  
SMART
  
PROSITE
  
PRINTS