CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021442
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Nucleolar protein 6 
Protein Synonyms/Alias
 Nucleolar RNA-associated protein; Nrap 
Gene Name
 NOL6 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
47TLAEPPAKGLLQPVKubiquitination[1]
54KGLLQPVKLSRAELYubiquitination[1]
62LSRAELYKEPTNEELubiquitination[1, 2]
93LQVEELLKEVRLSEKubiquitination[1, 2]
149HQVPYAVKGCFRFLPubiquitination[1, 3]
192PREILQDKDGLNQRYubiquitination[1]
271PCRLLPTKNNVRSAWubiquitination[1]
726SLLPRLDKPCPAYVEubiquitination[1]
788ATHTDVLKDGFVFRIubiquitination[1]
807QREPQILKEVQSPEGubiquitination[1, 2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094
Functional Description
  
Sequence Annotation
 MOD_RES 811 811 Phosphoserine.  
Keyword
 Alternative splicing; Chromosome; Coiled coil; Complete proteome; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; RNA-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1146 AA 
Protein Sequence
MGPAPAGEQL RGATGEPEVM EPALEGTGKE GKKASSRKRT LAEPPAKGLL QPVKLSRAEL 60
YKEPTNEELN RLRETEILFH SSLLRLQVEE LLKEVRLSEK KKDRIDAFLR EVNQRVVRVP 120
SVPETELTDQ AWLPAGVRVP LHQVPYAVKG CFRFLPPAQV TVVGSYLLGT CIRPDINVDV 180
ALTMPREILQ DKDGLNQRYF RKRALYLAHL AHHLAQDPLF GSVCFSYTNG CHLKPSLLLR 240
PRGKDERLVT VRLHPCPPPD FFRPCRLLPT KNNVRSAWYR GQSPAGDGSP EPPTPRYNTW 300
VLQDTVLESH LQLLSTILSS AQGLKDGVAL LKVWLRQREL DKGQGGFTGF LVSMLVVFLV 360
STRKIHTTMS GYQVLRSVLQ FLATTDLTVN GISLCLSSDP SLPALADFHQ AFSVVFLDSS 420
GHLNLCADVT ASTYHQVQHE ARLSMMLLDS RADDGFHLLL MTPKPMIRAF DHVLHLRPLS 480
RLQAACHRLK LWPELQDNGG DYVSAALGPL TTLLEQGLGA RLNLLAHSRP PVPEWDISQD 540
PPKHKDSGTL TLGLLLRPEG LTSVLELGPE ADQPEAAKFR QFWGSRSELR RFQDGAIREA 600
VVWEAASMSQ KRLIPHQVVT HLLALHADIP ETCVHYVGGP LDALIQGLKE TSSTGEEALV 660
AAVRCYDDLS RLLWGLEGLP LTVSAVQGAH PVLRYTEVFP PTPVRPAFSF YETLRERSSL 720
LPRLDKPCPA YVEPMTVVCH LEGSGQWPQD AEAVQRVRAA FQLRLAELLT QQHGLQCRAT 780
ATHTDVLKDG FVFRIRVAYQ REPQILKEVQ SPEGMISLRD TAASLRLERD TRQLPLLTSA 840
LHGLQQQHPA FSGVARLAKR WVRAQLLGEG FADESLDLVA AALFLHPEPF TPPSSPQVGF 900
LRFLFLVSTF DWKNNPLFVN LNNELTVEEQ VEIRSGFLAA RAQLPVMVIV TPQDRKNSVW 960
TQDGPSAQIL QQLVVLAAEA LPMLEKQLMD PRGPGDIRTV FRPPLDIYDV LIRLSPRHIP 1020
RHRQAVDSPA ASFCRGLLSQ PGPSSLMPVL GYDPPQLYLT QLREAFGDLA LFFYDQHGGE 1080
VIGVLWKPTS FQPQPFKASS TKGRMVMSRG GELVMVPNVE AILEDFAVLG EGLVQTVEAR 1140
SERWTV 1146 
Gene Ontology
 GO:0000794; C:condensed nuclear chromosome; ISS:UniProtKB.
 GO:0005730; C:nucleolus; ISS:UniProtKB.
 GO:0003723; F:RNA binding; ISS:UniProtKB.
 GO:0006364; P:rRNA processing; ISS:UniProtKB. 
Interpro
 IPR005554; Nrap. 
Pfam
 PF03813; Nrap 
SMART
  
PROSITE
  
PRINTS