CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020351
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Signal peptidase complex catalytic subunit SEC11C 
Protein Synonyms/Alias
 Microsomal signal peptidase 21 kDa subunit; SPase 21 kDa subunit; SEC11 homolog C; SEC11-like protein 3; SPC21 
Gene Name
 SEC11C 
Gene Synonyms/Alias
 SEC11L3; SPC21; SPCS4C 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
23LDIFGDLKKMNKRQLubiquitination[1, 2]
98AGEIVVFKVEGRDIPubiquitination[1, 2, 3, 4, 5]
112PIVHRVIKVHEKDNGubiquitination[4]
122EKDNGDIKFLTKGDNubiquitination[1, 2, 3, 4, 5]
126GDIKFLTKGDNNEVDubiquitination[1, 2, 4]
139VDDRGLYKEGQNWLEubiquitination[1, 2, 3, 5]
147EGQNWLEKKDVVGRAubiquitination[1, 4]
148GQNWLEKKDVVGRARubiquitination[4]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [5] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity). 
Sequence Annotation
 ACT_SITE 68 68 By similarity.  
Keyword
 Complete proteome; Endoplasmic reticulum; Hydrolase; Membrane; Microsome; Protease; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 192 AA 
Protein Sequence
MVRAGAVGAH LPASGLDIFG DLKKMNKRQL YYQVLNFAMI VSSALMIWKG LIVLTGSESP 60
IVVVLSGSME PAFHRGDLLF LTNFREDPIR AGEIVVFKVE GRDIPIVHRV IKVHEKDNGD 120
IKFLTKGDNN EVDDRGLYKE GQNWLEKKDV VGRARGFLPY VGMVTIIMND YPKFKYALLA 180
VMGAYVLLKR ES 192 
Gene Ontology
 GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
 GO:0050796; P:regulation of insulin secretion; TAS:Reactome.
 GO:0006465; P:signal peptide processing; IEA:InterPro.
 GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; TAS:Reactome.
 GO:0006412; P:translation; TAS:Reactome. 
Interpro
 IPR019758; Pept_S26A_signal_pept_1_CS.
 IPR019756; Pept_S26A_signal_pept_1_Ser-AS.
 IPR019759; Peptidase_S24_S26.
 IPR015927; Peptidase_S24_S26A/B/C.
 IPR011056; Peptidase_S24_S26A/B/C_b-rbn.
 IPR001733; Peptidase_S26B. 
Pfam
 PF00717; Peptidase_S24 
SMART
  
PROSITE
 PS00501; SPASE_I_1
 PS00761; SPASE_I_3 
PRINTS
 PR00728; SIGNALPTASE.