CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015213
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Putative deoxyribonuclease TATDN1 
Protein Synonyms/Alias
  
Gene Name
 Tatdn1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
27GIYRGVQKHQDDLQDacetylation[1]
27GIYRGVQKHQDDLQDsuccinylation[1]
46AIQIGVKKFMITGGSacetylation[1]
46AIQIGVKKFMITGGSsuccinylation[1]
46AIQIGVKKFMITGGSubiquitination[2]
Reference
 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Putative deoxyribonuclease (By similarity). 
Sequence Annotation
 METAL 112 112 Divalent metal cation 1 (By similarity).
 METAL 112 112 Divalent metal cation 2 (By similarity).
 METAL 149 149 Divalent metal cation 2 (By similarity).
 METAL 174 174 Divalent metal cation 2 (By similarity).
 METAL 222 222 Divalent metal cation 1 (By similarity).  
Keyword
 Alternative splicing; Complete proteome; Hydrolase; Metal-binding; Nuclease; Nucleus; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 295 AA 
Protein Sequence
MSLFKFVDIG INLTDPMFRG IYRGVQKHQD DLQDVIERAI QIGVKKFMIT GGSLQDSKDA 60
LQLAQTNDMF FSTVGCHPTR CDEFEKGSPD QYLAGLLSLA ENNKGKVVAI GECGLDFDRL 120
QFCPKDTQLK YFEKQFELSE QTQLPMFLHC RNSHTEFLDI MRRNRDRYVG GVVHSFDGTK 180
EAAAALVDLG LYIGFNGCSL KTEANLEVLK SIPSEKLMIE TDAPWCGVKS THAGSKYINT 240
SFPTKKKWEN GHCLKDRNEP CHIIQILEIM SAVREEDPLE LANTLYNNTI KVFFS 295 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0016888; F:endodeoxyribonuclease activity, producing 5'-phosphomonoesters; IEA:InterPro.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0090305; P:nucleic acid phosphodiester bond hydrolysis; IEA:GOC. 
Interpro
 IPR018228; DNase_TatD-rel_CS.
 IPR001130; TatD_family. 
Pfam
 PF01026; TatD_DNase 
SMART
  
PROSITE
 PS01090; TATD_2
 PS01091; TATD_3 
PRINTS