CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016718
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Kinetochore-associated protein 1 
Protein Synonyms/Alias
  
Gene Name
 Kntc1 
Gene Synonyms/Alias
 Kiaa0166 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
1316RHIIMELKEKSITFIacetylation[1]
Reference
 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377
Functional Description
 Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores (By similarity). 
Sequence Annotation
  
Keyword
 Cell cycle; Cell division; Centromere; Chromosome; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Kinetochore; Mitosis; Nucleus; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2207 AA 
Protein Sequence
MWNNIELLTS DDTGSGCLSV GSRKENVTAL YQADLLGKIS SEKTSLSPKI QAFSLSHGFI 60
IVADQSVILL DSICRSLQLF LIFDTDVDVV GLCQEGKFLF VGERSGNFHL IYVTSKQTLF 120
TKAFVEKALD ESQRTYRNLI IEKDGSNEGT YYMLLLTNNG FFYITNLQLS QIEQAIENTD 180
LDSAKKLQGQ FKCSFISTEN YHSCLSLVAS QSGTFASKTS VIIGGTGSCA FSKWEPDSTK 240
KEMSLKNFVG TDIIKGAKSF QLIDNLLFVL DTDNVLSLWD AYTLTPVWNW PSLPVEQFVL 300
TTEADSPSSV TWQGITNLKL VTLTATAKEK MRSLIIYSLP SMETLYSLEV SSVSSLVQTG 360
ISTDTIYLLE GIHKNDPNLC EDSVSDLVLR YLTEVLPENR LSRLLHKHRF AEAESFAIQF 420
GLDVELVYKV KSNDMLEKLA LISSDKSEQS KWQQLVDEAK ENLCKIQDDD FVVNFCLKAQ 480
WVTYETTQEM LSYAKTRLMK KEDRALPASS DAFMEVLKAH AKLTTFYGAF GPEKFSGSSW 540
IEFLNNEDDL RDVFLQLSEG NFACAQYLWL RHRADFESKF DVKMLENLLN SISTQFPLEN 600
LCSWFKNEVI PFVRRIVPEG QNILAKWLEQ ASRNLELTDK ANWPENGLQL AEVFFTAEKT 660
DRFGFASSWH WISLDYQNTE EVRQLRTLVS KLRELIILHR KYNCKLALSD FEKENATTVV 720
FRMFDRVSAP ELIPSVLEKS VRVYIREQNL QEEELLLLYI EDLLKRCSSK SMTLFDTAWE 780
AKAMAVIRCL SDTDLIFDAV LKIMYKAVVP WSAAVEQLVK QHLEMDHPKV KLLQESYKLM 840
EMKKLLRGYG IREVNLLNKE IMRVIRYILK QDIPSSLEDA LKVAQGYRLS DDEIYSLRII 900
DLIDREQGGD CLLLLKSLPA AEAEKTAERV IIWARLALQE EPDGSEEDKA WRISVAKTSV 960
DILKILCDIR KDNLQKKDES EEFLKRFQMV ASLQENFEVF LPFEDYSNTA LVAGLREQYI 1020
KAQEAAQAEH KHRGPPGPTP ARGTHLSIKS KLHRQALALQ VSEQELEAEL TLRALKDGKV 1080
VAALSKCRDL LKHYCNADTG RLLFVVCQKL CQMLADDVPM VAPGGLSLPS EIHDLACHAV 1140
TICSPDYLLD VLELSKYTLT AVELCRQCQM DDCGMLMKAA LGTHKDPYEE WSFSDFFSED 1200
GIVLESQVVL PVIYELISSV MPPAESKRHP LDSISLPYCS TSEGENRILP LVSSISALLR 1260
SLQECSQWEL ALRFVVGSFG TCLQHSMSNV MSISLSKQLL GKNTLANSRH IIMELKEKSI 1320
TFIRENATTL LHKVFNCRVV DLDLALAYCT LLPQKDVFDN LWKFIDKAWQ NYDKILALSL 1380
VGSQLANLYQ DIETGLWFHE LSIDAKWGIR LGKLGISFQP AFRQNFLTKK DLIKALVNNI 1440
DMDTSLILEY CSTFQLDSDA ALRLFIETLL RNTSSQSQGD AAPESTKHQH SKLLAKATEL 1500
VPLLKNTKDL VISLSEILYK LDPYDYEMID VVLKVLEQAN EKITSVNINQ ALNLLRHLKS 1560
YRRISPPVDH EYQYALEHMI TLPPAAHTRL PFHLILFGTA QNFWKILSSE LSEESLPTLL 1620
LIAKLMKFSL DTLYVSTAKH LFEKNLKPKL LKSAQARSST LMSKEVDKLM QTLESYLLSI 1680
VNPEWAVAIA ISLTQEVPEG PFKMSSLKFC LYLAERWLQN IPPQDETCEK AKALQKKLCL 1740
QVRLSGTEAV LIAHKLNDQE YLRVIGKPAH LIVSLYEHPS ISERLCTTSG KDYPDIHTAA 1800
KEIAEVNEVN LEKIWDMLLE KWLCPSTVPS EKASEFFELE EDEVLHRVVY LLQARPVDYC 1860
SRMLFVFATS ATSTLGMRQL TFAHKARALQ CLLYLADKET IESLFKKPIK EMKSYLKCIT 1920
FLASFETLNI PITYELFCNS PKEGMIKGLW KNHSHEPMAV RLVAELCLEY KIYDLQLWNG 1980
LLQKLLGFNM IPYLRKVLSC ISSIHSLWQV PYFSKAWQRV IQIPLLSASC PLRPSQLADC 2040
CDSLVAILEC PVSDDLDMMG VAKQYVQLDL PAFALTCLTL MPHSEKRHQQ IKNFLNSCDA 2100
RIILQQIEEH MNTGQLAGFS HQIGSLVLNH VVNKKEFGIL AKTKYFQLLK CHVINTGNVT 2160
ELVNYLANDF SVDEASALIN EYSKHCGKPV PADAAPCEIL QTFLGGS 2207 
Gene Ontology
 GO:0000777; C:condensed chromosome kinetochore; IEA:UniProtKB-SubCell.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005828; C:kinetochore microtubule; IEA:Compara.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0000922; C:spindle pole; IEA:Compara.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0007067; P:mitosis; IEA:UniProtKB-KW.
 GO:0007093; P:mitotic cell cycle checkpoint; IEA:Compara. 
Interpro
 IPR019527; RZZ-complex_KNTC1/ROD_C. 
Pfam
 PF10493; Rod_C 
SMART
  
PROSITE
  
PRINTS