Tag | Content |
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CPLM ID | CPLM-016718 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Kinetochore-associated protein 1 |
Protein Synonyms/Alias | |
Gene Name | Kntc1 |
Gene Synonyms/Alias | Kiaa0166 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
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1316 | RHIIMELKEKSITFI | acetylation | [1] |
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Reference | [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3. Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C. PLoS One. 2012;7(12):e50545. [ PMID: 23236377] |
Functional Description | Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores (By similarity). |
Sequence Annotation | |
Keyword | Cell cycle; Cell division; Centromere; Chromosome; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Kinetochore; Mitosis; Nucleus; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 2207 AA |
Protein Sequence | MWNNIELLTS DDTGSGCLSV GSRKENVTAL YQADLLGKIS SEKTSLSPKI QAFSLSHGFI 60 IVADQSVILL DSICRSLQLF LIFDTDVDVV GLCQEGKFLF VGERSGNFHL IYVTSKQTLF 120 TKAFVEKALD ESQRTYRNLI IEKDGSNEGT YYMLLLTNNG FFYITNLQLS QIEQAIENTD 180 LDSAKKLQGQ FKCSFISTEN YHSCLSLVAS QSGTFASKTS VIIGGTGSCA FSKWEPDSTK 240 KEMSLKNFVG TDIIKGAKSF QLIDNLLFVL DTDNVLSLWD AYTLTPVWNW PSLPVEQFVL 300 TTEADSPSSV TWQGITNLKL VTLTATAKEK MRSLIIYSLP SMETLYSLEV SSVSSLVQTG 360 ISTDTIYLLE GIHKNDPNLC EDSVSDLVLR YLTEVLPENR LSRLLHKHRF AEAESFAIQF 420 GLDVELVYKV KSNDMLEKLA LISSDKSEQS KWQQLVDEAK ENLCKIQDDD FVVNFCLKAQ 480 WVTYETTQEM LSYAKTRLMK KEDRALPASS DAFMEVLKAH AKLTTFYGAF GPEKFSGSSW 540 IEFLNNEDDL RDVFLQLSEG NFACAQYLWL RHRADFESKF DVKMLENLLN SISTQFPLEN 600 LCSWFKNEVI PFVRRIVPEG QNILAKWLEQ ASRNLELTDK ANWPENGLQL AEVFFTAEKT 660 DRFGFASSWH WISLDYQNTE EVRQLRTLVS KLRELIILHR KYNCKLALSD FEKENATTVV 720 FRMFDRVSAP ELIPSVLEKS VRVYIREQNL QEEELLLLYI EDLLKRCSSK SMTLFDTAWE 780 AKAMAVIRCL SDTDLIFDAV LKIMYKAVVP WSAAVEQLVK QHLEMDHPKV KLLQESYKLM 840 EMKKLLRGYG IREVNLLNKE IMRVIRYILK QDIPSSLEDA LKVAQGYRLS DDEIYSLRII 900 DLIDREQGGD CLLLLKSLPA AEAEKTAERV IIWARLALQE EPDGSEEDKA WRISVAKTSV 960 DILKILCDIR KDNLQKKDES EEFLKRFQMV ASLQENFEVF LPFEDYSNTA LVAGLREQYI 1020 KAQEAAQAEH KHRGPPGPTP ARGTHLSIKS KLHRQALALQ VSEQELEAEL TLRALKDGKV 1080 VAALSKCRDL LKHYCNADTG RLLFVVCQKL CQMLADDVPM VAPGGLSLPS EIHDLACHAV 1140 TICSPDYLLD VLELSKYTLT AVELCRQCQM DDCGMLMKAA LGTHKDPYEE WSFSDFFSED 1200 GIVLESQVVL PVIYELISSV MPPAESKRHP LDSISLPYCS TSEGENRILP LVSSISALLR 1260 SLQECSQWEL ALRFVVGSFG TCLQHSMSNV MSISLSKQLL GKNTLANSRH IIMELKEKSI 1320 TFIRENATTL LHKVFNCRVV DLDLALAYCT LLPQKDVFDN LWKFIDKAWQ NYDKILALSL 1380 VGSQLANLYQ DIETGLWFHE LSIDAKWGIR LGKLGISFQP AFRQNFLTKK DLIKALVNNI 1440 DMDTSLILEY CSTFQLDSDA ALRLFIETLL RNTSSQSQGD AAPESTKHQH SKLLAKATEL 1500 VPLLKNTKDL VISLSEILYK LDPYDYEMID VVLKVLEQAN EKITSVNINQ ALNLLRHLKS 1560 YRRISPPVDH EYQYALEHMI TLPPAAHTRL PFHLILFGTA QNFWKILSSE LSEESLPTLL 1620 LIAKLMKFSL DTLYVSTAKH LFEKNLKPKL LKSAQARSST LMSKEVDKLM QTLESYLLSI 1680 VNPEWAVAIA ISLTQEVPEG PFKMSSLKFC LYLAERWLQN IPPQDETCEK AKALQKKLCL 1740 QVRLSGTEAV LIAHKLNDQE YLRVIGKPAH LIVSLYEHPS ISERLCTTSG KDYPDIHTAA 1800 KEIAEVNEVN LEKIWDMLLE KWLCPSTVPS EKASEFFELE EDEVLHRVVY LLQARPVDYC 1860 SRMLFVFATS ATSTLGMRQL TFAHKARALQ CLLYLADKET IESLFKKPIK EMKSYLKCIT 1920 FLASFETLNI PITYELFCNS PKEGMIKGLW KNHSHEPMAV RLVAELCLEY KIYDLQLWNG 1980 LLQKLLGFNM IPYLRKVLSC ISSIHSLWQV PYFSKAWQRV IQIPLLSASC PLRPSQLADC 2040 CDSLVAILEC PVSDDLDMMG VAKQYVQLDL PAFALTCLTL MPHSEKRHQQ IKNFLNSCDA 2100 RIILQQIEEH MNTGQLAGFS HQIGSLVLNH VVNKKEFGIL AKTKYFQLLK CHVINTGNVT 2160 ELVNYLANDF SVDEASALIN EYSKHCGKPV PADAAPCEIL QTFLGGS 2207 |
Gene Ontology | GO:0000777; C:condensed chromosome kinetochore; IEA:UniProtKB-SubCell. GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0005828; C:kinetochore microtubule; IEA:Compara. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0000922; C:spindle pole; IEA:Compara. GO:0051301; P:cell division; IEA:UniProtKB-KW. GO:0007067; P:mitosis; IEA:UniProtKB-KW. GO:0007093; P:mitotic cell cycle checkpoint; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |