CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023321
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Superoxide dismutase [Mn], mitochondrial 
Protein Synonyms/Alias
  
Gene Name
 sod2 
Gene Synonyms/Alias
 SPAC1486.01 
Created Date
 July 27, 2013 
Organism
 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 
NCBI Taxa ID
 284812 
Lysine Modification
Position
Peptide
Type
References
25IARGVHTKATLPPLPacetylation[1]
121VTSGSLHKAITSKWGacetylation[1]
126LHKAITSKWGSLEDFacetylation[1]
156WAWLIVDKDGSLRITacetylation[1]
175QDTIVKSKPIIGIDAacetylation[1]
Reference
 [1] Mitochondrial localization of fission yeast manganese superoxide dismutase is required for its lysine acetylation and for cellular stress resistance and respiratory growth.
 Takahashi H, Suzuki T, Shirai A, Matsuyama A, Dohmae N, Yoshida M.
 Biochem Biophys Res Commun. 2011 Mar 4;406(1):42-6. [PMID: 21295010] 
Functional Description
 Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. 
Sequence Annotation
 METAL 50 50 Manganese (By similarity).
 METAL 96 96 Manganese (By similarity).
 METAL 181 181 Manganese (By similarity).
 METAL 185 185 Manganese (By similarity).
 MOD_RES 129 129 Phosphoserine.  
Keyword
 Complete proteome; Direct protein sequencing; Manganese; Metal-binding; Mitochondrion; Oxidoreductase; Phosphoprotein; Reference proteome; Transit peptide. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 218 AA 
Protein Sequence
MLRFLSKNSV AAIRNVSIAR GVHTKATLPP LPYAYNALEP ALSETIMKLH HDKHHQTYVN 60
NLNAAQEKLA DPNLDLEGEV ALQAAIKFNG GGHINHSLFW KILAPQKEGG GKPVTSGSLH 120
KAITSKWGSL EDFQKEMNAA LASIQGSGWA WLIVDKDGSL RITTTANQDT IVKSKPIIGI 180
DAWEHAYYPQ YENRKAEYFK AIWNVINWKE AESRYSNR 218 
Gene Ontology
 GO:0005759; C:mitochondrial matrix; ISO:PomBase.
 GO:0030145; F:manganese ion binding; ISS:PomBase.
 GO:0004784; F:superoxide dismutase activity; ISO:PomBase.
 GO:0001320; P:age-dependent response to reactive oxygen species involved in chronological cell aging; ISO:PomBase.
 GO:0006801; P:superoxide metabolic process; IC:PomBase. 
Interpro
 IPR001189; Mn/Fe_SOD.
 IPR019833; Mn/Fe_SOD_BS.
 IPR019832; Mn/Fe_SOD_C.
 IPR019831; Mn/Fe_SOD_N. 
Pfam
 PF02777; Sod_Fe_C
 PF00081; Sod_Fe_N 
SMART
  
PROSITE
 PS00088; SOD_MN 
PRINTS
 PR01703; MNSODISMTASE.