CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014912
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Putative peptidyl-tRNA hydrolase PTRHD1 
Protein Synonyms/Alias
 Peptidyl-tRNA hydrolase domain-containing protein 1 
Gene Name
 PTRHD1 
Gene Synonyms/Alias
 C2orf79 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
134EEVGQYLKKFRLFK*acetylation[1, 2, 3, 4]
Reference
 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Hydrolase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 140 AA 
Protein Sequence
MHRGVGPAFR VVRKMAASGA EPQVLVQYLV LRKDLSQAPF SWPAGALVAQ ACHAATAALH 60
THRDHPHTAA YLQELGRMRK VVLEAPDETT LKELAETLQQ KNIDHMLWLE QPENIATCIA 120
LRPYPKEEVG QYLKKFRLFK 140 
Gene Ontology
 GO:0004045; F:aminoacyl-tRNA hydrolase activity; IEA:EC.
 GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
 GO:0035335; P:peptidyl-tyrosine dephosphorylation; IEA:GOC. 
Interpro
 IPR023476; Pep_tRNA_hydro_II_dom.
 IPR002833; Pep_tRNA_hydro_PTH2.
 IPR017867; Tyr_phospatase_low_mol_wt. 
Pfam
 PF01981; PTH2 
SMART
  
PROSITE
  
PRINTS