| Tag | Content |
|---|
| CPLM ID | CPLM-005243 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Transcription elongation factor A protein 3 |
Protein Synonyms/Alias | Transcription elongation factor S-II protein 3; Transcription elongation factor TFIIS.h |
Gene Name | Tcea3 |
Gene Synonyms/Alias | Tfiish |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 199 | EMLSAALKAEDNFKD | phosphoglycerylation | [1] |
|
Reference | [1] Functional lysine modification by an intrinsically reactive primary glycolytic metabolite. Moellering RE, Cravatt BF. Science. 2013 Aug 2;341(6145):549-53. [ PMID: 23908237] |
Functional Description | Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus. |
Sequence Annotation | DOMAIN 5 82 TFIIS N-terminal.
DOMAIN 186 302 TFIIS central.
ZN_FING 305 345 TFIIS-type. |
Keyword | 3D-structure; Complete proteome; DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription; Transcription regulation; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 347 AA |
Protein Sequence | MGLEEELLRI AKKLEKMVSR KKTEGALDLL KKLNSCQMSI QLLQTTRIGV AVNGVRKHCS 60
DKEVVSLAKV LIKNWKRLLD SPRTTKGERE EREKAKKEKG LGCSDWKPEA GLSPPRKKGG 120
GEPKTRRDSV DSRSSTTSSP KRPSLERSNS SKSKVETPTT PSSPSTPTFA PAVCLLAPCY 180
LTGDSVRDKC VEMLSAALKA EDNFKDYGVN CDKLASEIED HIYQELKSTD MKYRNRVRSR 240
ISNLKDPRNP GLRRNVLSGA ISPELIAKMT AEEMASDELR ELRNAMTQEA IREHQMAKTG 300
GTTTDLLRCS KCKKKNCTYN QVQTRSADEP MTTFVLCNEC GNRWKFC 347 |
Gene Ontology | GO:0005634; C:nucleus; IDA:MGI. GO:0003677; F:DNA binding; IEA:UniProtKB-KW. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0032784; P:regulation of DNA-dependent transcription, elongation; IEA:InterPro. GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IEA:InterPro. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
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PROSITE | |
PRINTS | |