CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014149
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 DNA polymerase sigma 
Protein Synonyms/Alias
 DNA polymerase kappa; LAK-1; PAP-associated domain-containing protein 7; Terminal uridylyltransferase 5; TUTase 5; Topoisomerase-related function protein 4-1; TRF4-1 
Gene Name
 PAPD7 
Gene Synonyms/Alias
 POLS; TRF4 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
70LLEQALRKHNVAEPCubiquitination[1]
84CSIKVLDKATVPIIKubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 DNA polymerase, probably involved in DNA repair. May play a role in sister chromatid cohesion. Does not play a role in replication-dependent histone mRNA degradation. 
Sequence Annotation
 DOMAIN 178 238 PAP-associated.
 METAL 47 47 Magnesium or manganese; catalytic (By
 METAL 49 49 Magnesium or manganese; catalytic (By  
Keyword
 Cell cycle; Cell division; Complete proteome; DNA synthesis; DNA-binding; DNA-directed DNA polymerase; Magnesium; Manganese; Metal-binding; Mitosis; Nucleotidyltransferase; Nucleus; Polymorphism; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 542 AA 
Protein Sequence
MSPCPEEAAM RREVVKRIET VVKDLWPTAD VQIFGSFSTG LYLPTSDIDL VVFGKWERPP 60
LQLLEQALRK HNVAEPCSIK VLDKATVPII KLTDQETEVK VDISFNMETG VRAAEFIKNY 120
MKKYSLLPYL ILVLKQFLLQ RDLNEVFTGG ISSYSLILMA ISFLQLHPRI DARRADENLG 180
MLLVEFFELY GRNFNYLKTG IRIKEGGAYI AKEEIMKAMT SGYRPSMLCI EDPLLPGNDV 240
GRSSYGAMQV KQVFDYAYIV LSHAVSPLAR SYPNRDAEST LGRIIKVTQE VIDYRRWIKE 300
KWGSKAHPSP GMDSRIKIKE RIATCNGEQT QNREPESPYG QRLTLSLSSP QLLSSGSSAS 360
SVSSLSGSDV DSDTPPCTTP SVYQFSLQAP APLMAGLPTA LPMPSGKPQP TTSRTLIMTT 420
NNQTRFTIPP PTLGVAPVPC RQAGVEGTAS LKAVHHMSSP AIPSASPNPL SSPHLYHKQH 480
NGMKLSMKGS HGHTQGGGYS SVGSGGVRPP VGNRGHHQYN RTGWRRKKHT HTRDSLPVSL 540
SR 542 
Gene Ontology
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0043221; F:SMC family protein binding; TAS:UniProtKB.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
 GO:0006302; P:double-strand break repair; NAS:UniProtKB.
 GO:0007076; P:mitotic chromosome condensation; NAS:UniProtKB.
 GO:0042493; P:response to drug; IDA:UniProtKB.
 GO:0007062; P:sister chromatid cohesion; TAS:UniProtKB. 
Interpro
 IPR002934; Nucleotidyltransferase.
 IPR002058; PAP_assoc. 
Pfam
 PF01909; NTP_transf_2
 PF03828; PAP_assoc 
SMART
  
PROSITE
  
PRINTS