| Tag | Content |
|---|
| CPLM ID | CPLM-006821 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Sulfite reductase [NADPH] flavoprotein alpha-component |
Protein Synonyms/Alias | SiR-FP |
Gene Name | cysJ |
Gene Synonyms/Alias | STM2948 |
Created Date | July 27, 2013 |
Organism | Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) |
NCBI Taxa ID | 99287 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 246 | ATLSVNQKITGRNSE | acetylation | [1] |
|
Reference | [1] Regulation of cellular metabolism by protein lysine acetylation. Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL. Science. 2010 Feb 19;327(5968):1000-4. [ PMID: 20167786] |
Functional Description | Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component. |
Sequence Annotation | DOMAIN 64 202 Flavodoxin-like.
DOMAIN 234 448 FAD-binding FR-type.
NP_BIND 70 74 FMN (By similarity).
NP_BIND 117 122 FMN (By similarity).
NP_BIND 150 181 FMN (By similarity).
NP_BIND 386 389 FAD (By similarity).
NP_BIND 420 422 FAD (By similarity).
NP_BIND 519 527 NADP (By similarity).
BINDING 489 489 NADP (By similarity). |
Keyword | Amino-acid biosynthesis; Complete proteome; Cysteine biosynthesis; Electron transport; FAD; Flavoprotein; FMN; NADP; Oxidoreductase; Reference proteome; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 599 AA |
Protein Sequence | MTTPAPLTGL LPLNPEQLAR LQAATTDLTP EQLAWVSGYF WGVLNPRSGA VAVTPVPERK 60
MPRVTLISAS QTGNARRVAE ALRDDLLAAN LNVTLVNAGD YKFKQIASEK LLVIVTSTQG 120
EGEPPEEAVA LHKFLFSKKA PKLENTAFAV FSLGDTSYEF FCQSGKDFDS KLAELGGERL 180
LDRVDADVEY QAAASEWRAR VVDVLKSRAP VAAPSQSVAT GAVNDIHTSP YTKDAPLIAT 240
LSVNQKITGR NSEKDVRHIE IDLGDSGLRY QPGDALGVWY QNDPALVKEL VELLWLKGDE 300
PVTVDGKTLP LAEALEWHFE LTVNTANIVE NYATLTRSES LLPLVGDKAQ LQHYAATTPI 360
VDMVRFSPAQ LDAQALIDLL RPLTPRLYSI ASAQAEVESE VHITVGVVRY DIEGRARAGG 420
ASSFLADRVE EEGEVRVFIE HNDNFRLPAN PETPVIMIGP GTGIAPFRSF MQQRAAEGVE 480
GKNWLFFGNP HFTEDFLYQV EWQRYVKEGV LSRIDLAWSR DQKEKIYVQD KLREQGAELW 540
RWINDGAHIY VCGDARRMAA DVEKALLEVI AEFGGMDLES ADEYLSELRV ERRYQRDVY 599 |
Gene Ontology | GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro. GO:0010181; F:FMN binding; IEA:InterPro. GO:0005506; F:iron ion binding; IEA:InterPro. GO:0004783; F:sulfite reductase (NADPH) activity; IEA:HAMAP. GO:0019344; P:cysteine biosynthetic process; IEA:UniProtKB-KW. GO:0022900; P:electron transport chain; IEA:UniProtKB-KW. GO:0070814; P:hydrogen sulfide biosynthetic process; IEA:HAMAP. GO:0000103; P:sulfate assimilation; IEA:HAMAP. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |