Tag | Content |
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CPLM ID | CPLM-000214 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Betaine--homocysteine S-methyltransferase 1 |
Protein Synonyms/Alias | |
Gene Name | Bhmt |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
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7 | *MAPIAGKKAKRGIL | acetylation | [1] | 40 | LEKRGYVKAGPWTPE | acetylation | [1] | 82 | TFYASEDKLENRGNY | acetylation | [1] | 93 | RGNYVAEKISGQKVN | acetylation | [1] | 139 | KSETEVKKIFHQQLE | acetylation | [1] | 150 | QQLEVFMKKNVDFLI | acetylation | [1] | 232 | LQTIKLMKEGLEAAR | acetylation | [1] | 327 | FLPPASEKHGSWGSG | acetylation | [1] | 340 | SGLDMHTKPWIRARA | acetylation | [1] | 349 | WIRARARKEYWQNLR | acetylation | [1] | 369 | PYNPSMSKPDAWGVT | acetylation | [1] | 386 | AAELMQQKEATTEQQ | acetylation | [1] | 400 | QLRALFEKQKFKSAQ | acetylation | [1] |
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Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline. |
Sequence Annotation | DOMAIN 11 314 Hcy-binding. METAL 217 217 Zinc. METAL 299 299 Zinc. METAL 300 300 Zinc. |
Keyword | 3D-structure; Complete proteome; Cytoplasm; Metal-binding; Methyltransferase; Reference proteome; Transferase; Zinc. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 407 AA |
Protein Sequence | MAPIAGKKAK RGILERLNAG EVVIGDGGFV FALEKRGYVK AGPWTPEAAV EHPEAVRQLH 60 REFLRAGSNV MQTFTFYASE DKLENRGNYV AEKISGQKVN EAACDIARQV ADEGDALVAG 120 GVSQTPSYLS CKSETEVKKI FHQQLEVFMK KNVDFLIAEY FEHVEEAVWA VEALKTSGKP 180 IAATMCIGPE GDLHGVSPGE CAVRLVKAGA AIVGVNCHFD PSTSLQTIKL MKEGLEAARL 240 KAYLMSHALA YHTPDCGKQG FIDLPEFPFG LEPRVATRWD IQKYAREAYN LGVRYIGGCC 300 GFEPYHIRAI AEELAPERGF LPPASEKHGS WGSGLDMHTK PWIRARARKE YWQNLRIASG 360 RPYNPSMSKP DAWGVTKGAA ELMQQKEATT EQQLRALFEK QKFKSAQ 407 |
Gene Ontology | GO:0005829; C:cytosol; IDA:RGD. GO:0043234; C:protein complex; IDA:RGD. GO:0047150; F:betaine-homocysteine S-methyltransferase activity; IDA:RGD. GO:0008898; F:homocysteine S-methyltransferase activity; IEA:InterPro. GO:0032403; F:protein complex binding; IDA:RGD. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0006579; P:amino-acid betaine catabolic process; IEA:UniProtKB-UniPathway. GO:0009086; P:methionine biosynthetic process; IDA:RGD. GO:0006479; P:protein methylation; IDA:RGD. GO:0010243; P:response to organic nitrogen; IEP:RGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |