| Tag | Content |
|---|
| CPLM ID | CPLM-008899 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Origin recognition complex subunit 3 |
Protein Synonyms/Alias | Origin recognition complex 62 kDa subunit |
Gene Name | ORC3 |
Gene Synonyms/Alias | OAF1; OIF1; YLL004W; L1365 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 56 | ESEVNVEKRWELYHQ | ubiquitination | [1] |
|
Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. Binds to the ARS consensus sequence (ACS) of origins of replication. |
Sequence Annotation | |
Keyword | Complete proteome; Direct protein sequencing; DNA replication; DNA-binding; Nucleus; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 616 AA |
Protein Sequence | MSDLNQSKKM NVSEFADAQR SHYTVYPSLP QSNKNDKHIP FVKLLSGKES EVNVEKRWEL 60
YHQLHSHFHD QVDHIIDNIE ADLKAEISDL LYSETTQKRR CFNTIFLLGS DSTTKIELKD 120
ESSRYNVLIE LTPKESPNVR MMLRRSMYKL YSAADAEEHP TIKYEDINDE DGDFTEQNND 180
VSYDLSLVEN FKRLFGKDLA MVFNFKDVDS INFNTLDNFI ILLKSAFKYD HVKISLIFNI 240
NTNLSNIEKN LRQSTIRLLK RNYHKLDVSS NKGFKYGNQI FQSFLDTVDG KLNLSDRFVE 300
FILSKMANNT NHNLQLLTKM LDYSLMSYFF QNAFSVFIDP VNVDFLNDDY LKILSRCPTF 360
MFFVEGLIKQ HAPADEILSL LTNKNRGLEE FFVEFLVREN PINGHAKFVA RFLEEELNIT 420
NFNLIELYHN LLIGKLDSYL DRWSACKEYK DRLHFEPIDT IFQELFTLDN RSGLLTQSIF 480
PSYKSNIEDN LLSWEQVLPS LDKENYDTLS GDLDKIMAPV LGQLFKLYRE ANMTINIYDF 540
YIAFRETLPK EEILNFIRKD PSNTKLLELA ETPDAFDKVA LILFMQAIFA FENMGLIKFQ 600
STKSYDLVEK CVWRGI 616 |
Gene Ontology | GO:0031261; C:DNA replication preinitiation complex; IDA:SGD. GO:0005664; C:nuclear origin of replication recognition complex; IMP:SGD. GO:0005656; C:pre-replicative complex; IDA:SGD. GO:0003682; F:chromatin binding; IDA:SGD. GO:0003688; F:DNA replication origin binding; IDA:SGD. GO:0030466; P:chromatin silencing at silent mating-type cassette; IDA:SGD. GO:0006270; P:DNA replication initiation; IMP:SGD. GO:0006267; P:pre-replicative complex assembly; IDA:SGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |