CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038146
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Epoxide hydrolase 1 
Protein Synonyms/Alias
  
Gene Name
 Ephx1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
142LPSGRTPKPLLMVHGubiquitination[1]
197FSEASSKKGLNSVATubiquitination[1]
210ATARIFYKLMSRLGFacetylation[2]
263RFLGYTEKDLELLYPubiquitination[1]
272LELLYPFKEKVFYNIubiquitination[1]
274LLYPFKEKVFYNIMRubiquitination[1]
320EKFSTWTKSEYRELEacetylation[3]
320EKFSTWTKSEYRELEubiquitination[1]
361VSSQRFYKENLGQGVubiquitination[1]
397EILHAPEKWVKVKYPubiquitination[1]
405WVKVKYPKLISYSYMacetylation[3]
405WVKVKYPKLISYSYMubiquitination[1]
425FAAFEEPKLLAQDIRacetylation[3, 4]
425FAAFEEPKLLAQDIRubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [3] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [4] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 441 AA 
Protein Sequence
MWLELILASV LGFVIYWFVS RDKEETLPLE DGWWGPGSKP SAKEDESIRP FKVETSDEEI 60
KDLHQRIDRF RASPPLEGSR FHYGFNSSYL KKVVSFWRNE FDWRKQVEIL NQYPHFKTKI 120
EGLDIHFIHV KPPQLPSGRT PKPLLMVHGW PGSFYEFYKI IPLLTDPKTH GLSDEHVFEV 180
ICPSIPGYGF SEASSKKGLN SVATARIFYK LMSRLGFQKF YIQGGDWGSL ICTNIAQMVP 240
KNIYSLTPLL GQRFGRFLGY TEKDLELLYP FKEKVFYNIM RESGYLHIQA TKPDTVGCAL 300
NDSPVGLAAY ILEKFSTWTK SEYRELEDGG LERKFSLEDL LTNIMIYWTT GTIVSSQRFY 360
KENLGQGVMV HRHEGMKVFV PTGYSAFPSE ILHAPEKWVK VKYPKLISYS YMERGGHFAA 420
FEEPKLLAQD IRKFVSLAEL Q 441 
Gene Ontology
 GO:0033961; F:cis-stilbene-oxide hydrolase activity; IEA:InterPro.
 GO:0006725; P:cellular aromatic compound metabolic process; IMP:MGI.
 GO:0014070; P:response to organic cyclic compound; IMP:MGI. 
Interpro
 IPR000073; AB_hydrolase_1.
 IPR000639; Epox_hydrolase-like.
 IPR010497; Epoxide_hydro_N.
 IPR016292; Epoxide_hydrolase. 
Pfam
 PF00561; Abhydrolase_1
 PF06441; EHN 
SMART
  
PROSITE
  
PRINTS
 PR00412; EPOXHYDRLASE.