UniProt Accession

 KCC2G_MOUSE; Q923T9; Q3U3H3; Q8VED3 

Genbank Protein ID

 AF395884; AK154764; BC019162; BC025597 

Genbank Nucleotide ID

 AAK84142.1; BAE32813.1; AAH19162.1; AAH25597.1 

Protein Name

 Calcium/calmodulin-dependent protein kinase type II subunit gamma 

Protein Synonyms/Alias

 CaM kinase II subunit gamma; CaMK-II subunit gamma 

Gene Name

 Camk2g 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
43	STQEYAAKIINTKKL	ubiquitination	[1]
48	AAKIINTKKLSARDH	ubiquitination	[1]
268	ITADQALKHPWVCQR	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity. In slow- twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin. In neurons, may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning (By similarity). 

Sequence Annotation

 DOMAIN 14 272 Protein kinase.
 NP_BIND 20 28 ATP (By similarity).
 REGION 283 292 Autoinhibitory domain (By similarity).
 REGION 291 301 Calmodulin-binding (By similarity).
 ACT_SITE 136 136 Proton acceptor (By similarity).
 BINDING 43 43 ATP (By similarity).
 MOD_RES 235 235 Phosphoserine.
 MOD_RES 287 287 Phosphothreonine; by autocatalysis
 MOD_RES 306 306 Phosphothreonine; by autocatalysis (By
 MOD_RES 307 307 Phosphothreonine; by autocatalysis (By
 MOD_RES 311 311 Phosphoserine (By similarity).
 MOD_RES 349 349 Phosphoserine (By similarity).
 MOD_RES 352 352 Phosphoserine (By similarity).  

Keyword

 Alternative splicing; ATP-binding; Calmodulin-binding; Complete proteome; Developmental protein; Differentiation; Kinase; Membrane; Neurogenesis; Nucleotide-binding; Phosphoprotein; Reference proteome; Sarcoplasmic reticulum; Serine/threonine-protein kinase; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 529 AA 

Protein Sequence

Gene Ontology

 GO:0033017; C:sarcoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004683; F:calmodulin-dependent protein kinase activity; IEA:EC.
 GO:0004674; F:protein serine/threonine kinase activity; IMP:MGI.
 GO:0006816; P:calcium ion transport; IMP:MGI.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:0000082; P:G1/S transition of mitotic cell cycle; IMP:MGI.
 GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
 GO:0046777; P:protein autophosphorylation; IMP:MGI. 

Interpro

 IPR020636; Ca/CaM-dep_Ca-dep_prot_Kinase.
 IPR013543; Ca/CaM-dep_prot_kinase-assoc.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 

Pfam

 PF08332; CaMKII_AD
 PF00069; Pkinase 

SMART

 SM00220; S_TKc 

PROSITE

 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 

PRINTS