CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005655
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc finger protein 2 
Protein Synonyms/Alias
 Zinc finger homeodomain protein 2 
Gene Name
 zfh2 
Gene Synonyms/Alias
 zfh-2; CG1449 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
1299SDGPVGIKQERLEQEacetylation[1]
1839QKANLPMKVVKHWFRacetylation[1]
2117KKMQIVGKTFEKNVAacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702
Functional Description
 Involved in the development of the embryonic central nervous system. 
Sequence Annotation
 ZN_FING 133 156 C2H2-type 1.
 ZN_FING 559 582 C2H2-type 2.
 ZN_FING 614 638 C2H2-type 3.
 ZN_FING 732 756 C2H2-type 4.
 ZN_FING 897 916 C2H2-type 5; degenerate.
 ZN_FING 940 964 C2H2-type 6.
 ZN_FING 999 1023 C2H2-type 7.
 ZN_FING 1074 1098 C2H2-type 8.
 ZN_FING 1210 1233 C2H2-type 9.
 ZN_FING 1341 1365 C2H2-type 10.
 ZN_FING 1438 1462 C2H2-type 11.
 ZN_FING 1477 1500 C2H2-type 12; degenerate.
 ZN_FING 1513 1535 C2H2-type 13.
 ZN_FING 1541 1564 C2H2-type 14.
 DNA_BIND 1797 1856 Homeobox 1.
 DNA_BIND 2154 2213 Homeobox 2.
 ZN_FING 2234 2256 C2H2-type 15.
 ZN_FING 2371 2393 C2H2-type 16.
 DNA_BIND 2760 2819 Homeobox 3.
 MOD_RES 1337 1337 Phosphothreonine.
 MOD_RES 2361 2361 Phosphoserine.
 MOD_RES 2450 2450 Phosphoserine.
 MOD_RES 2451 2451 Phosphoserine.
 MOD_RES 2749 2749 Phosphoserine.
 MOD_RES 2751 2751 Phosphoserine.  
Keyword
 Complete proteome; DNA-binding; Homeobox; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 3005 AA 
Protein Sequence
MSSFDVETFN GKIVYNLDGS AHIIATDNTN GGGSGSGQNC YGSTTNSLKN LSKDKGRGQE 60
EKDIEHPSQY HREQSDNKRQ EEAVDNRPGV ESLGSACYKS SPKIHSFRVV SAQDANSTCQ 120
DQIRAFKIQK PILMCFICKL SFGNVKSFSL HANTEHRLNL EELDQQLLNR EYSSAIIQRN 180
MDEKPQISFL QPLANNDASA DTNDTEKLQT ATEGSDATLP SSPQPVFRNV SELEPENKQE 240
TEQNRLLNQD REQEPESDQH TSSSKMAAPS AYIPLSSPKV AGKLTVKFGS LNSATAKTNN 300
LSKVSSTSSP PSTYASGEVL SPSTDNISNH KSTHCNQETE PPSSSSSEVE MKIGSMSTSP 360
QTNDSDVPCS GFLQMQHMTT GGAYTPQVSS FHASLAALAA NESNDNRVKL ITEFLQQQLQ 420
QHQSSLFPSP CPDHPDLNGV DCKTCELLDI QQRSKSPSSS HHQFSQSLPQ LQIQSQPQQT 480
PHRSPCSNSV ALPVSPSASS VASVGNASTA TSSFTIGACS EHINGRPQGV DCARCEMLLN 540
SARLNSGVQM STRNSCKTLK CPQCNWHYKY QETLEIHMRE KHPDGESACG YCLAGQQHPR 600
LARGESYSCG YKPYRCEICN YSTTTKGNLS IHMQSDKHLN NMQELNSSQN MVAAAAAAAV 660
TGKLLLSSSS PQVTAACPSN SGSGAGSGSS NIVGGTASLS GNATPSVTGA NSSNANAGSN 720
TNNAGTKPKP SFRCDICSYD TSVARNLRIH MTSEKHTHNM AVLQNNIKHI QAFNFLQQQQ 780
QSGTGNIASH SSGSFMPEVA LADLAYNQAL MIQLLHQQQQ HQQSANTKLS PSSSPVSTPD 840
QFSFSPKPIK LNHGTGAAMG IGMAMGMGMS HSNEVSCELS GDPHPLTKTD KWPMAFYSCL 900
VCDCYSTNNL DDLNQHLLLD RSRQSSSASS EIMVIHNNNY ICRLCNYKTN LKANFQLHSK 960
TDKHLQKLNF INHIREGGPQ NEYKMQYQQQ QLAANVVQLK CNCCDFHTNS IQKLSLHTQQ 1020
MRHDTMRMIF QHLLYIVQQS EMHNKSSGSA EDDPQCACPD EDQQLQLQSS KKLLLCQLCN 1080
FTAQNIHEMV QHVKGIRHLQ VEQFICLQRR SENQEIPALN EVFKVTEWVM ENEDVSLAPG 1140
LNLARTTTND ATTDASYAAA SSAAVPAIPD VSMFSPTSPS SCATSCDKNL SQIVLPNVNN 1200
LGSGVPTTVF KCNLCEYFVQ SKSEIAAHIE TEHSCAESDE FITIPTNTAA LQAFQTAVAA 1260
AALAAVHQRC AVINPPTQDT VDEDKDLDTN VSDGPVGIKQ ERLEQEVDRT TSMDVTKDLA 1320
SQATDFGAPE SPKVAETEVG VQCPLCLENH FREKQYLEDH LTSVHSVTRD GLSRLLLLVD 1380
QKALKKESTD IACPTDKAPY ANTNALERAP TPIENTCNVS LIKSTSANPS QSVSLQGLSC 1440
QQCEASFKHE EQLLKHAQQN QHFSLQNGEY LCLAASHISR PCFMTFRTIP TMISHFQDLH 1500
MSLIISERHV YKYRCKQCSL AFKTQEKLTT HMLYHSMRDA TKCSFCQRNF RSTQALQKHM 1560
EQAHAEDGTP STRTNSPQTP MLSTEETHKH LLAESHAVER EVSGSDVSPI ELETHLNKET 1620
RHLSPTPMSL DSQSHQKHLA TFAALLKQQQ CNSDAGGLHP EALSMSTGEM PPQLQGLQNL 1680
QHIQQHFGAV AAAAGLPINP VDMLNIMQFH HLMSLNFMNL APPLVFGANA AGNAVSGPSA 1740
LNNSITTSTA TSASGLGDTH LTSGVSSIPV DSGKATAVPP QTQLNANANS QQLASNQKRA 1800
RTRITDDQLK ILRAHFDINN SPSEESIMEM SQKANLPMKV VKHWFRNTLF KERQRNKDSP 1860
YNFNNPPSTT LNLEEYERTG QAKVTPLNDT CSVAVTGPMT SSTISLPPSG NINLSSKENA 1920
TSKVLAAGKA NASGPVTFSA TVPVSTPLSR PESTNSSGNI SDYIGNNIFF GQLGSKEQIL 1980
PYSLDGQIKS EPQDDMIGAT DFAYQTKQHS SFSFLKQQQD LVDPPEQCLT NQNADTAQDQ 2040
SLLAGSSLAS NCQSQQQINI FETKSESGSS DVLSRPPSPN SGAAGNVYGS MNDLLNQQLE 2100
NMGSNMGPPK KMQIVGKTFE KNVAPMVTSG SVSTQFESNS SNSSSSSSST SGGKRANRTR 2160
FTDYQIKVLQ EFFENNSYPK DSDLEYLSKL LLLSPRVIVV WFQNARQKQR KIYENQPNNT 2220
LFENEETKKQ NINYACKKCN LVFQRYYELI RHQKNHCFKE ENNKKSAKAQ IAAAQIAQNL 2280
SSEDSNSSMD IHHVGICPPG SAVASHTLST PGSAAPLPGQ YTQHSFGALP SPQHLFAKSS 2340
SLTDFSPSTT PTPPQRERSN SLDQIQRPPK FDCDKCELNF NQLEKLREHQ LLHLMNPGNI 2400
CSDVGQNSNP EANFGPFGSI LQSLQQAAAQ QQQQHHQQPP TKKRKYSDCS SNADEMQSLS 2460
ELEASQKKHE YLYKYFMQNE TSQEVKQQFL MQQQQKKLEQ GNECDFELDF LTNFYQQNEL 2520
KKVSNYDFLL QYYRTHEEAK SSQQHTFSSS KKPTIEFLLQ YYQLNESKKF FQLVASPQII 2580
PDVPGYKPSL RIPKSTSDEA PYIGETSLEQ ATELQREKQD EQLRIDRPSE ENDLSMNKNK 2640
VENINNNNIN VDQSNLTETN GGVPSVETKE ECTQESSLIA MDDENKYLCT RSKQKDDKEK 2700
SHYLHNLEDF LDATMIENNS QTLTFNDDEK ACQKDELTQN SNAIEKRSSV SPVNVSSKQN 2760
KRLRTTILPE QLNFLYECYQ SESNPSRKML EEISKKVNLK KRVVQVWFQN SRAKDKKSRN 2820
QRHYAHISDD NSYDGSSGKE VYSDLRSNGI TVDTDLETNL QDCQLCQVTQ VNIRKHAFSV 2880
EHISKMKKLL EQTTELYAQS NGSGSEDNDS DREKRFYNLS KAFLLQHVVT NATSHAIHTA 2940
RQDSDVIAEG NCILNYDTNG GDSKSHVQHN LPNEVVSEDA RKIAGNQELM QQLFNRNHIT 3000
VIGGK 3005 
Gene Ontology
 GO:0005634; C:nucleus; IDA:FlyBase.
 GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; IDA:FlyBase.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0007476; P:imaginal disc-derived wing morphogenesis; IMP:FlyBase.
 GO:0007399; P:nervous system development; IEP:FlyBase. 
Interpro
 IPR017970; Homeobox_CS.
 IPR001356; Homeodomain.
 IPR009057; Homeodomain-like.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
 PF00046; Homeobox
 PF00096; zf-C2H2 
SMART
 SM00389; HOX
 SM00355; ZnF_C2H2 
PROSITE
 PS00027; HOMEOBOX_1
 PS50071; HOMEOBOX_2
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS