UniProt Accession

 KAD_MYCS2; A0QSH8; I7G444 

Genbank Protein ID

 CP000480; CP001663 

Genbank Nucleotide ID

 ABK75327.1; AFP37921.1 

Protein Name

 Adenylate kinase 

Protein Synonyms/Alias

 AK; ATP-AMP transphosphorylase; ATP:AMP phosphotransferase; Adenylate monophosphate kinase 

Gene Name

 adk 

Gene Synonyms/Alias

 MSMEG_1484; MSMEI_1448 

Created Date

 July 27, 2013 

Organism

 Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) 

NCBI Taxa ID

 246196 

Lysine Modification

Position	Peptide	Type	References
23	QAEKLSEKLGIPQIS	pupylation	[1]

Reference

 [1] Proteome-wide identification of mycobacterial pupylation targets.
 Poulsen C, Akhter Y, Jeon AH, Schmitt-Ulms G, Meyer HE, Stefanski A, Stühler K, Wilmanns M, Song YH.
 Mol Syst Biol. 2010 Jul 13;6:386. [PMID: 20631680] 

Functional Description

 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity). 

Sequence Annotation

 NP_BIND 10 15 ATP (By similarity).
 NP_BIND 57 59 AMP (By similarity).
 NP_BIND 85 88 AMP (By similarity).
 REGION 30 59 NMPbind (By similarity).
 REGION 126 132 LID (By similarity).
 BINDING 31 31 AMP (By similarity).
 BINDING 36 36 AMP (By similarity).
 BINDING 92 92 AMP (By similarity).
 BINDING 127 127 ATP (By similarity).
 BINDING 129 129 AMP (By similarity).
 BINDING 140 140 AMP (By similarity).
 BINDING 166 166 ATP; via carbonyl oxygen (By similarity).  

Keyword

 ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide biosynthesis; Nucleotide-binding; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 181 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0004017; F:adenylate kinase activity; IEA:HAMAP.
 GO:0005524; F:ATP binding; IEA:HAMAP.
 GO:0044209; P:AMP salvage; IEA:UniProtKB-UniPathway. 

Interpro

 IPR000850; Adenylate_kin.
 IPR027417; P-loop_NTPase. 

Pfam

 PF00406; ADK 

SMART

  

PROSITE

 PS00113; ADENYLATE_KINASE 

PRINTS

 PR00094; ADENYLTKNASE.