UniProt Accession

 PPR27_HUMAN; Q86WC6 

Genbank Protein ID

 AF434846; BC093707; BC112094 

Genbank Nucleotide ID

 AAO67357.1; AAH93707.1; AAI12095.1 

Protein Name

 Protein phosphatase 1 regulatory subunit 27 

Protein Synonyms/Alias

 Dysferlin-interacting protein 1; Toonin 

Gene Name

 PPP1R27 

Gene Synonyms/Alias

 DYSFIP1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
85	ECVKLLVKYGADIHQ	ubiquitination	[1, 2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. 

Sequence Annotation

 REPEAT 63 92 ANK 1.
 REPEAT 96 125 ANK 2.  

Keyword

 ANK repeat; Complete proteome; Protein phosphatase inhibitor; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 154 AA 

Protein Sequence

Gene Ontology

 GO:0019902; F:phosphatase binding; IDA:UniProtKB.
 GO:0004864; F:protein phosphatase inhibitor activity; IEA:UniProtKB-KW.
 GO:0010923; P:negative regulation of phosphatase activity; IDA:UniProtKB. 

Interpro

 IPR002110; Ankyrin_rpt.
 IPR020683; Ankyrin_rpt-contain_dom. 

Pfam

 PF12796; Ank_2 

SMART

 SM00248; ANK 

PROSITE

 PS50297; ANK_REP_REGION
 PS50088; ANK_REPEAT 

PRINTS