UniProt Accession

 ELF2_HUMAN; Q15723; Q15724; Q15725; Q6P1K5 

Genbank Protein ID

 U43188; U43189; U43189; AF256222; AF256223; BC034951; BC065025 

Genbank Nucleotide ID

 AAB37759.1; AAB37760.1; AAB37761.1; AAF67195.1; AAF67196.1; AAH34951.1; AAH65025.1 

Protein Name

 ETS-related transcription factor Elf-2 

Protein Synonyms/Alias

 E74-like factor 2; New ETS-related factor 

Gene Name

 ELF2 

Gene Synonyms/Alias

 NERF 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
197	GSPELGIKKKPREGK	ubiquitination	[1]
198	SPELGIKKKPREGKG	ubiquitination	[2]
248	VDSKAVSKLWGKHKN	ubiquitination	[2]
279	YQRGILAKVEGQRLV	ubiquitination	[3]
290	QRLVYQFKDMPKNIV	ubiquitination	[2]
294	YQFKDMPKNIVVIDD	ubiquitination	[2]
318	LAGTTDEKSLERVSL	ubiquitination	[2]
332	LSAESLLKAASSVRS	ubiquitination	[2, 3]
451	ASTENGDKITMQPAK	ubiquitination	[2]
531	RVISAVIKGPEVKSE	ubiquitination	[2]
557	TLQLVEEKPADGNKT	ubiquitination	[2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 

Functional Description

 Isoform 1 transcriptionally activates the LYN and BLK promoters and acts synergistically with RUNX1 to transactivate the BLK promoter. 

Sequence Annotation

 DNA_BIND 208 290 ETS.
 MOD_RES 185 185 Phosphoserine.
 MOD_RES 191 191 Phosphoserine.
 MOD_RES 372 372 Phosphoserine.
 MOD_RES 430 430 Phosphoserine.  

Keyword

 Activator; Alternative splicing; Complete proteome; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 593 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005634; C:nucleus; IC:UniProtKB.
 GO:0043565; F:sequence-specific DNA binding; IDA:UniProtKB.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:UniProtKB.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:UniProtKB.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:UniProtKB.
 GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR000418; Ets_dom.
 IPR022084; TF_Elf_N.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF12310; Elf-1_N
 PF00178; Ets 

SMART

 SM00413; ETS 

PROSITE

 PS00345; ETS_DOMAIN_1
 PS00346; ETS_DOMAIN_2
 PS50061; ETS_DOMAIN_3 

PRINTS

 PR00454; ETSDOMAIN.