UniProt Accession

 RAC2_MOUSE; Q05144; Q3TBC4; Q9D8X9 

Genbank Protein ID

 X53247; AK007561; AK144136; AK171321; BC005455 

Genbank Nucleotide ID

 CAA37337.1; BAB25109.1; BAE25721.1; BAE42390.1; AAH05455.1 

Protein Name

 Ras-related C3 botulinum toxin substrate 2 

Protein Synonyms/Alias

 Protein EN-7; p21-Rac2 

Gene Name

 Rac2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
123	KLDLRDDKDTIEKLK	ubiquitination	[1]
128	DDKDTIEKLKEKKLA	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase. 

Sequence Annotation

 NP_BIND 10 17 GTP (By similarity).
 NP_BIND 57 61 GTP (By similarity).
 NP_BIND 115 118 GTP (By similarity).
 MOTIF 32 40 Effector region (Potential).
 MOD_RES 147 147 N6-acetyllysine (By similarity).
 MOD_RES 189 189 Cysteine methyl ester (By similarity).
 LIPID 189 189 S-geranylgeranyl cysteine (By  

Keyword

 Acetylation; Complete proteome; Cytoplasm; GTP-binding; Lipoprotein; Membrane; Methylation; Nucleotide-binding; Prenylation; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 192 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0016020; C:membrane; IDA:MGI.
 GO:0005635; C:nuclear envelope; IDA:MGI.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; IDA:MGI.
 GO:0030036; P:actin cytoskeleton organization; IDA:MGI.
 GO:0045453; P:bone resorption; IEA:Compara.
 GO:0030031; P:cell projection assembly; IDA:MGI.
 GO:0006935; P:chemotaxis; IDA:MGI.
 GO:0008284; P:positive regulation of cell proliferation; IMP:MGI.
 GO:0060263; P:regulation of respiratory burst; IEA:Compara.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR003578; Small_GTPase_Rho. 

Pfam

 PF00071; Ras 

SMART

 SM00174; RHO 

PROSITE

 PS51420; RHO 

PRINTS

 PR00449; RASTRNSFRMNG.