CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017631
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 RING finger protein 214 
Protein Synonyms/Alias
  
Gene Name
 RNF214 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
246RYQEVLDKQRQVENQubiquitination[1]
259NQLQVQLKQLQQRREubiquitination[1, 2, 3, 4]
298KKIEKEKKEFLQKEQubiquitination[2, 4]
331EMELDRLKNQDGEINubiquitination[1]
350EETERAWKAEILSLEubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789
Functional Description
  
Sequence Annotation
 ZN_FING 658 700 RING-type; atypical.
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 47 47 Phosphoserine.
 MOD_RES 497 497 Phosphoserine.
 MOD_RES 511 511 Phosphoserine.
 MOD_RES 516 516 Phosphoserine.  
Keyword
 Acetylation; Coiled coil; Complete proteome; Metal-binding; Phosphoprotein; Reference proteome; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 703 AA 
Protein Sequence
MAASEVAGVV ANAPSPPESS SLCASKSDEG LPDGLSTKDS AQKQKNSPLL SVSSQTITKE 60
NNRNVHLEHS EQNPGSSAGD TSAAHQVVLG ENLIATALCL SGSGSQSDLK DVASTAGEEG 120
DTSLRESLHP VTRSLKAGCH TKQLASRNCS EEKSPQTSIL KEGNRDTSLD FRPVVSPANG 180
VEGVRVDQDD DQDSSSLKLS QNIAVQTDFK TADSEVNTDQ DIEKNLDKMM TERTLLKERY 240
QEVLDKQRQV ENQLQVQLKQ LQQRREEEMK NHQEILKAIQ DVTIKREETK KKIEKEKKEF 300
LQKEQDLKAE IEKLCEKGRR EVWEMELDRL KNQDGEINRN IMEETERAWK AEILSLESRK 360
ELLVLKLEEA EKEAELHLTY LKSTPPTLET VRSKQEWETR LNGVRIMKKN VRDQFNSHIQ 420
LVRNGAKLSS LPQIPTPTLP PPPSETDFML QVFQPSPSLA PRMPFSIGQV TMPMVMPSAD 480
PRSLSFPILN PALSQPSQPS SPLPGSHGRN SPGLGSLVSP HGPHMPPAAS IPPPPGLGGV 540
KASAETPRPQ PVDKLEKILE KLLTRFPQCN KAQMTNILQQ IKTARTTMAG LTMEELIQLV 600
AARLAEHERV AASTQPLGRI RALFPAPLAQ ISTPMFLPSA QVSYPGRSSH APATCKLCLM 660
CQKLVQPSEL HPMACTHVLH KECIKFWAQT NTNDTCPFCP TLK 703 
Gene Ontology
 GO:0008270; F:zinc ion binding; IEA:InterPro. 
Interpro
 IPR001841; Znf_RING.
 IPR013083; Znf_RING/FYVE/PHD. 
Pfam
  
SMART
 SM00184; RING 
PROSITE
 PS00518; ZF_RING_1
 PS50089; ZF_RING_2 
PRINTS