| Tag | Content |
|---|
| CPLM ID | CPLM-006687 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Tumor necrosis factor receptor superfamily member 3 |
Protein Synonyms/Alias | Lymphotoxin-beta receptor; Tumor necrosis factor C receptor; Tumor necrosis factor receptor 2-related protein; Tumor necrosis factor receptor type III; TNF-RIII; TNFR-III |
Gene Name | LTBR |
Gene Synonyms/Alias | D12S370; TNFCR; TNFR3; TNFRSF3 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 71 | PGTYVSAKCSRIRDT | ubiquitination | [1] |
|
Reference | [1] Global identification of modular cullin-RING ligase substrates. Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ. Cell. 2011 Oct 14;147(2):459-74. [ PMID: 21963094] |
Functional Description | Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs. |
Sequence Annotation | REPEAT 42 81 TNFR-Cys 1.
REPEAT 82 124 TNFR-Cys 2.
REPEAT 125 168 TNFR-Cys 3.
REPEAT 169 211 TNFR-Cys 4.
MOD_RES 323 323 Phosphoserine.
CARBOHYD 40 40 N-linked (GlcNAc...) (Potential).
CARBOHYD 177 177 N-linked (GlcNAc...) (Potential).
DISULFID 43 58 By similarity.
DISULFID 59 72 By similarity.
DISULFID 62 80 By similarity.
DISULFID 83 98 By similarity.
DISULFID 101 116 By similarity.
DISULFID 104 124 By similarity.
DISULFID 126 132 By similarity.
DISULFID 139 148 By similarity.
DISULFID 142 167 By similarity.
DISULFID 170 185 By similarity. |
Keyword | 3D-structure; Alternative splicing; Apoptosis; Complete proteome; Disulfide bond; Glycoprotein; Host-virus interaction; Membrane; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 435 AA |
Protein Sequence | MLLPWATSAP GLAWGPLVLG LFGLLAASQP QAVPPYASEN QTCRDQEKEY YEPQHRICCS 60
RCPPGTYVSA KCSRIRDTVC ATCAENSYNE HWNYLTICQL CRPCDPVMGL EEIAPCTSKR 120
KTQCRCQPGM FCAAWALECT HCELLSDCPP GTEAELKDEV GKGNNHCVPC KAGHFQNTSS 180
PSARCQPHTR CENQGLVEAA PGTAQSDTTC KNPLEPLPPE MSGTMLMLAV LLPLAFFLLL 240
ATVFSCIWKS HPSLCRKLGS LLKRRPQGEG PNPVAGSWEP PKAHPYFPDL VQPLLPISGD 300
VSPVSTGLPA APVLEAGVPQ QQSPLDLTRE PQLEPGEQSQ VAHGTNGIHV TGGSMTITGN 360
IYIYNGPVLG GPPGPGDLPA TPEPPYPIPE EGDPGPPGLS TPHQEDGKAW HLAETEHCGA 420
TPSNRGPRNQ FITHD 435 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0006915; P:apoptotic process; IEA:UniProtKB-KW. GO:0071260; P:cellular response to mechanical stimulus; IEP:UniProtKB. GO:2001238; P:positive regulation of extrinsic apoptotic signaling pathway; IMP:UniProtKB. GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IEP:UniProtKB. GO:0046330; P:positive regulation of JNK cascade; IMP:UniProtKB. GO:0007165; P:signal transduction; TAS:ProtInc. GO:0019048; P:virus-host interaction; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |