CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011214
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Translation termination inhibitor protein ITT1 
Protein Synonyms/Alias
  
Gene Name
 ITT1 
Gene Synonyms/Alias
 YML068W 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
23MYPELEMKSVKVEEEubiquitination[1, 2]
151LFPNGIRKCLTQDQYubiquitination[2]
172SEEATLQKVSRSNYHubiquitination[2]
288QAATRLSKYCPYACVubiquitination[2]
Reference
 [1] Systematic approach for validating the ubiquitinated proteome.
 Seyfried NT, Xu P, Duong DM, Cheng D, Hanfelt J, Peng J.
 Anal Chem. 2008 Jun 1;80(11):4161-9. [PMID: 18433149]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 Modulates the efficiency of translation termination, resulting in the readthrough of all three types of nonsense codons UAA, UAG and UGA. 
Sequence Annotation
 ZN_FING 180 232 RING-type 1.
 ZN_FING 272 338 IBR-type.
 ZN_FING 402 431 RING-type 2; degenerate.  
Keyword
 Complete proteome; Metal-binding; Reference proteome; Repeat; Translation regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 464 AA 
Protein Sequence
MALTQFENDL EILRDMYPEL EMKSVKVEEE GEFPQRINGK LLFKISLLAD VNIEFGEQHM 60
LLSNLSNECV EFTIYSCHYP DIRRCVVMDI KSLWISTDEK KMLIDKALRL VEETVDMSIE 120
FADSFTSILI LIFGFLIDDT AILLFPNGIR KCLTQDQYDL FKQISEEATL QKVSRSNYHC 180
CICMEMEKGV RMIKLPCENA NVEHYLCRGC AKSYFTAMIQ ENRISSVRCP QCEYKELKLE 240
DFKSYKKMLK ALFTPLIPVS FLKEVIDTEL CERYEKMFYN QAATRLSKYC PYACVTCRRC 300
DSWCTKEDLD DAMIQCQKCH FVFCFDCLHA WHGYNNKCGK KVSLSTDIIE EYLDDTVTSY 360
ERKRKLEAKY GRRVLELEVN DYLAEKMLDL AIKKEGSNLQ RCPKCKVVVE RSEGCNKMKC 420
EVCGTLFCFI CGVLLYPEDP YEHFREAYSG CYGRLFEGMP GTET 464 
Gene Ontology
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006449; P:regulation of translational termination; IMP:SGD. 
Interpro
 IPR002867; Znf_C6HC.
 IPR001841; Znf_RING. 
Pfam
 PF01485; IBR 
SMART
 SM00647; IBR
 SM00184; RING 
PROSITE
 PS00518; ZF_RING_1
 PS50089; ZF_RING_2 
PRINTS