CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040476
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Helicase POLQ-like 
Protein Synonyms/Alias
  
Gene Name
 Helq 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
261SEEISVAKKAIESPSacetylation[1]
441ILEMTLAKVLYTSKTacetylation[2]
Reference
 [1] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Helicase; Hydrolase; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 972 AA 
Protein Sequence
XDGCPRIRRR VSVRKRNRGN LENLRASPTP AELQPAEDTE DEAAAGSRRR KTGSPEHAQE 60
NDSEEDMFGD YDSFTESSFL AHVDDLEQRY MQLPECGDRD ADSGTKDLCS AGLKNNLRVT 120
TVINLTDPET SEHGQKQSHL DVPAEPEPGS DLSFDVPSSQ ILYFENPQNS PEALGDPCTK 180
KTNGDPQKSS HEELVSSHTE QPEPNNDFSN VRAASESSRR KSLKDHLKST MAGNARAQTP 240
AFPRSKHLRE ALLSEEISVA KKAIESPSDD LGPFYSLPSK VRDLYVQLKG IKKLYDWQHT 300
CLTLRSVQER KNLIYSLPTS GGKTLVAEIL MLQELLCRQK DVLMILPYVA IVQEKISSLS 360
SFGIELGFFV EEYAGSKGRF PPIKRREKKS LYIATIEKAH SLVNALIETS RLSTLGLVVV 420
DELHMIGEGS RGAILEMTLA KVLYTSKTTQ IIGMSATLNN VEDLQAFLKA EYYTSQFRPV 480
ELKEFLKVND TIYEVDSQAA DGMTFSRLLS YKYSEALKKM DPDRLVALVT EVIPNYSCLV 540
FCPSKKNCEN VAEMLCKFLS KDYLNHREKE KCEVIKSLRN IGNGKVCPVL KRTVPFGIAY 600
HHSGLTSEER KLLEEAYSTG VLCLLTCTST LAAGVNLPAR RVILRAPYVA NTFLKRNQYK 660
QMVGRAGRAG IDTAGESILL LQEKDKQQVL ELISGPLETC CSHLVEEFTK GIQALFLSLI 720
GLKIAASLGD IYQFMSGTFF GVQQKILLKE KSLWEITVDA LEHLTEKGLL QKDSCGDNEG 780
LECHFRITKL GQASFKGAID LAYCDTLYRD LKKGLEGLVL ESLLHLIYLT TPYDLAAQSE 840
PDWMVYFKQF GQLSPTEQNV AALLGVSESF IGKKAAGQAV RKGRAKQLYN AGYRSIMHLA 900
NANPEVLVKT IDHLSRRQAR QIVSSAKMLL HEKAEALQGE AEELLRLPAD LPGLGGPSSE 960
RAGSHAGDVT LS 972 
Gene Ontology
 GO:0017117; C:single-stranded DNA-dependent ATP-dependent DNA helicase complex; ISO:MGI.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0003676; F:nucleic acid binding; IEA:InterPro.
 GO:0017116; F:single-stranded DNA-dependent ATP-dependent DNA helicase activity; ISO:MGI. 
Interpro
 IPR011545; DNA/RNA_helicase_DEAD/DEAH_N.
 IPR014001; Helicase_ATP-bd.
 IPR001650; Helicase_C.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00270; DEAD
 PF00271; Helicase_C 
SMART
 SM00487; DEXDc
 SM00490; HELICc 
PROSITE
 PS51192; HELICASE_ATP_BIND_1
 PS51194; HELICASE_CTER 
PRINTS