CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023517
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Eukaryotic translation initiation factor 4H 
Protein Synonyms/Alias
 eIF-4H; Williams-Beuren syndrome chromosomal region 1 protein homolog 
Gene Name
 Eif4h 
Gene Synonyms/Alias
 Wbscr1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
80VRDKDTDKFKGFCYVacetylation[1]
123AEGRKQDKGGFGFRKacetylation[1]
Reference
 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
 Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA (By similarity). 
Sequence Annotation
 DOMAIN 42 118 RRM.
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 21 21 Phosphoserine (By similarity).
 MOD_RES 24 24 Phosphoserine (By similarity).
 MOD_RES 32 32 Phosphoserine (By similarity).  
Keyword
 3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Initiation factor; Phosphoprotein; Protein biosynthesis; Reference proteome; RNA-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 248 AA 
Protein Sequence
MADFDTYDDR AYSSFGGGRG SRGSAGGHGS RSQKELPTEP PYTAYVGNLP FNTVQGDIDA 60
IFKDLSIRSV RLVRDKDTDK FKGFCYVEFD EVDSLKEALT YDGALLGDRS LRVDIAEGRK 120
QDKGGFGFRK GGPDDRGMGG SRESRGGWDS RDDFNSGYRD DFLGGRGGSR PGDRRAGPPM 180
GSRFRDGPPL RGSNMDFREP TEEERAQRPR LQLKPRTVAT PLNQVANPNS AIFGGARPRE 240
EVVQKEQE 248 
Gene Ontology
 GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
 GO:0048589; P:developmental growth; IMP:MGI.
 GO:0019953; P:sexual reproduction; IMP:MGI. 
Interpro
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 
Pfam
 PF00076; RRM_1 
SMART
 SM00360; RRM 
PROSITE
 PS50102; RRM 
PRINTS