CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-034668
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ferrochelatase 
Protein Synonyms/Alias
  
Gene Name
 Fech 
Gene Synonyms/Alias
 Fech_predicted; rCG_46783 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
303YRLVWQSKVGPVPWLacetylation[1]
378NGNPLFSKALADLVHacetylation[1]
414NPVCRKTKSFFTSQQacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Catalyzes the ferrous insertion into protoporphyrin IX (By similarity). 
Sequence Annotation
  
Keyword
 Complete proteome; Heme biosynthesis; Iron; Lyase; Porphyrin biosynthesis; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 422 AA 
Protein Sequence
MLSAGANMAA ALRAAGALFR EPLVYGSSRA CQPWRCQSGP AVVATTEKAH HAKTTKPQAQ 60
PERRKPKTGI LMLNMGGPET LGEVQDFLQR LFLDRDLMTL PIQNKLAPFI AKRRTPKIQE 120
QYRRIGGGSP IKMWTSKQGE GMVKLLDELS PDTAPHKYYI GFRYVHPLTE EAIEEMERDG 180
LERAIAFTQY PQYSCSTTGS SLNAIYRYYN EVGRKPTMKW STIDRWPTHP LLIQCFADHI 240
LKELDHFPEE KRSEVVILFS AHSLPMSVVN RGDPYPQEVG ATVHRVMEQL GYPNPYRLVW 300
QSKVGPVPWL GPQTDEAIKG LCERGRKNIL LVPIAFTSDH IETLYELDIE YSQVLAQKCG 360
AENIRRAESL NGNPLFSKAL ADLVHSHIQS NKLCSTQLSL SCPLCVNPVC RKTKSFFTSQ 420
QL 422 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:RGD.
 GO:0004325; F:ferrochelatase activity; IDA:RGD.
 GO:0020037; F:heme binding; IEA:Compara.
 GO:0005506; F:iron ion binding; IEA:Compara.
 GO:0030350; F:iron-responsive element binding; IEA:Compara.
 GO:0071549; P:cellular response to dexamethasone stimulus; IEP:RGD.
 GO:0008203; P:cholesterol metabolic process; IEA:Compara.
 GO:0009589; P:detection of UV; IEA:Compara.
 GO:0030218; P:erythrocyte differentiation; IEA:Compara.
 GO:0006783; P:heme biosynthetic process; IDA:RGD.
 GO:0055072; P:iron ion homeostasis; IEA:Compara.
 GO:0046501; P:protoporphyrinogen IX metabolic process; IEA:Compara.
 GO:0010999; P:regulation of eIF2 alpha phosphorylation by heme; IEA:Compara.
 GO:0046984; P:regulation of hemoglobin biosynthetic process; IEA:Compara.
 GO:0046685; P:response to arsenic-containing substance; IEP:RGD.
 GO:0042493; P:response to drug; IEP:RGD.
 GO:0045471; P:response to ethanol; IEP:RGD.
 GO:0017085; P:response to insecticide; IEP:RGD.
 GO:0010288; P:response to lead ion; IEP:RGD.
 GO:0051597; P:response to methylmercury; IEP:RGD.
 GO:0070541; P:response to platinum ion; IEP:RGD.
 GO:0034379; P:very-low-density lipoprotein particle assembly; IEA:Compara. 
Interpro
 IPR001015; Ferrochelatase.
 IPR019772; Ferrochelatase_AS. 
Pfam
 PF00762; Ferrochelatase 
SMART
  
PROSITE
 PS00534; FERROCHELATASE 
PRINTS