| Tag | Content |
|---|
| CPLM ID | CPLM-013181 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Ubiquitin-associated and SH3 domain-containing protein A |
Protein Synonyms/Alias | Suppressor of T-cell receptor signaling 2; STS-2; T-cell ubiquitin ligand 1; TULA-1 |
Gene Name | Ubash3a |
Gene Synonyms/Alias | Sts2 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 202 | LHLTLAHKFYPHHQR | ubiquitination | [1] |
|
Reference | [1] BTB-ZF factors recruit the E3 ligase cullin 3 to regulate lymphoid effector programs. Mathew R, Seiler MP, Scanlon ST, Mao AP, Constantinides MG, Bertozzi-Villa C, Singer JD, Bendelac A. Nature. 2012 Nov 22;491(7425):618-21. [ PMID: 23086144] |
Functional Description | Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain (By similarity). Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. |
Sequence Annotation | DOMAIN 19 60 UBA.
DOMAIN 238 303 SH3.
REGION 358 624 Phosphatase-like. |
Keyword | 3D-structure; Complete proteome; Cytoplasm; Nucleus; Reference proteome; SH3 domain. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 624 AA |
Protein Sequence | MAAGETQLYA KVSNKLKGRS TPSLLDPLLA MGFPTHTALK ALAATGRKTA EAAADWLHGH 60
CNDPSLDDPI PQEYALFLCP TGPLLEKLQE FWRESRRQCA KNRAHEVFPH VTLCDFFTCE 120
DQKVECLYEA LRRAGDRILG SFPTLVPLVL HSSISYLGFF INDSPADAIR EFAMAFATEA 180
AVLADCTIKP CTKQLHLTLA HKFYPHHQRT LEQLAKAIQP SHSCQWTAAL YSRDMRFVHY 240
QTLKALFQYK PQNADELMLS AGDYIFVDPT QQEEASEGWA IGISHRTGCR GFLPENYTER 300
ANEADTWVKH RTYTFNLAMD LNSRKDFEAS CRGNGEPHTP SMSKSVSSIQ ALQATISRRG 360
ILVVRHGERV DQVFGKSWLQ QCTTADGKYY RPDLNFPRSL PRRSNGIKDF ENDPPLSSCG 420
IFQARLAGEA LLDSGVRVTA VFASPALRCV QTAKHILEEL KLEKKLKIRV EPGIFEWMKW 480
EASKATLTFL TLEELKEANF NVDLDYRPAL PRCSLMPAES YDQYVERCAV SMGQIINTCP 540
QDMGITLIVS HSSALDSCTR PLLGLPPREC GDFAQLVRKI PSLGMCFCEE NREDGKWDLV 600
NPPVKTLTHG ANSVFNWRNW ISSN 624 |
Gene Ontology | GO:0005829; C:cytosol; IEA:Compara. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0003824; F:catalytic activity; IEA:InterPro. GO:0050860; P:negative regulation of T cell receptor signaling pathway; IGI:MGI. GO:0001817; P:regulation of cytokine production; IGI:MGI. GO:0016070; P:RNA metabolic process; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |